Abi-1 Antibody

Rabbit Polyclonal

Catalog Number

251822

Unit

0.1 mg

Price

$245.00

Isotype

Rabbit Ig

Applications

E, WB, IHC

Species reactivity

H, M, R

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 5% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Data and Images

Abi-1 staining in rat brain: Paraffin-embedded rat brain is stained with Abi-1 Antibody (Cat. No. 251822) used at 1:200 dilution.Abi-1 staining in rat brain: Paraffin-embedded rat brain is stained with Abi-1 Antibody (Cat. No. 251822) used at 1:200 dilution.

Description

Abl interactor 1 (Abi-1) negatively regulates cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Abi-1 plays a role in regulation of EGF-induced Erk pathway activation. Abi-1 is involved in cytoskeletal reorganization and EGFR signaling, and together with EPS8 participates in transduction of signals from Ras to Rac. A chromosomal aberration involving Abi-1 is a cause of acute leukemias.


Alternate Names

Abl interactor 1; Abelson interactor 1; Abi-1; Spectrin SH3 domain-binding protein 1; Eps8 SH3 domain-binding protein; Eps8-binding protein; e3B1; Nap1-binding protein; Nap1BP; Abl-binding protein 4; AblBP4; ABI1; SSH3BP1

Accession No.

Q8IZP0

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Abi-1.

Application Notes

E: 1:500-1:1,000
WB: 1:100-1:500
IHC: 1:100-1:500
ICC: 1:100-1:500

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Cytoskeleton Proteins,  Cell Growth & Death, Signal Transduction

For research use only, not for diagnostic or therapeutic procedures.