ADAM-TS7 Antibody

Catalog Number

250456

Unit

0.1 mg

Price

$265.00

Isotype

Applications

Species reactivity

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Description

A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAM-TS7) is a metalloprotease that degrades COMP. ADAM-TS7 is up-regulated in articular cartilage and synovium from arthritis patients. The spacer domain and the thrombospondin type-1 domain are important for a tight interaction with the extracellular matrix. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Alternate Names

A disintegrin and metalloproteinase with thrombospondin motifs 7; ADAMTS-7; ADAM-TS 7; ADAM-TS7; COMPase; ADAMTS7

Accession No.

Q9UKP4

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human ADAM-TS7.

Application Notes

E: 1:500-1:1,000

WB: 1:100-1:500

IHC: 1:100-1:500

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.