AIF Antibody

Catalog Number

250464

Unit

0.1 mg

Price

$231.00

Isotype

Applications

Species reactivity

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Description

Apoptosis-inducing factor (AIF) is a mitochondrial protein that translocates to the nucleus upon induction of apoptosis. It has been demonstrated that AIF causes DNA fragmentation and chromatin condensation, and induces the release of cytochrome c and caspase-9 from mitochondria. Release of AIF from mitochondria was shown to be prevented by over-expression of Bcl-2, a protein involved in mitochondrial permeability.

Alternate Names

Apoptosis-inducing factor 1; Programmed cell death protein 8; AIFM1; AIF; PDCD8

Accession No.

O95831

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human AIF protein.

Application Notes

E: 1:200-1:500

WB: 1:200-1:500

IHC: 1:500-1:1,001

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.