BRCA1 Antibody

Catalog Number

200160

Unit

0.1 mg

Price

$220.00

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Data and Images

Description

Breast cancer type 1 susceptibility protein (BRCA1) plays a central role in DNA repair by facilitating cellular response to DNA repair. BRCA1 is required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. BRCA1 is part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. Defects in BRCA1 are a cause of genetic susceptibility to breast and ovarian cancers.

Product Citations

Recommended Products

200163 NBS1 Antibody
200167 MLH1 Antibody
200166 MSH2 Antibody

Alternate Names

Breast cancer type 1 susceptibility protein; RING finger protein 53; BRCA1; RNF53

Accession No.

P38398
NP_009225

Clonality

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human BRCA1.

Application Notes

E: 1:500-1:1,000

WB: 1:100-1:500

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.