CD31 (N-term) Antibody

Rabbit Polyclonal

Catalog Number

250589

Unit

0.1 mg

Price

$231.00

Isotype

Rabbit Ig

Applications

E, WB, IHC

Species reactivity

H, M, R, Other

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Data and Images

CD31 staining in mouse melanoma and rat fat tissue: Vascular endothelial cells in paraffin-embedded mouse melanoma (top) and rat fat tissue (bottom) are stained with CD31 (N-term) Antibody (Cat. No. 250589) used at a 1:200 dilution.CD31 staining in mouse melanoma and rat fat tissue: Vascular endothelial cells in paraffin-embedded mouse melanoma (top) and rat fat tissue (bottom) are stained with CD31 (N-term) Antibody (Cat. No. 250589) used at a 1:200 dilution.

Description

CD31 (PECAM1) is a member of the immunoglobulin (Ig) superfamily that is expressed on the surface of circulating platelets, monocytes, neutrophils, and particular T-cell subsets. CD31 is also a major constituent of the endothelial cell intercellular junction, where up to an estimated 1 million molecules are concentrated. Because of this cellular expression pattern, CD31 is implicated in several functions, including transendothelial migration of leukocytes, angiogenesis, and integrin activation. Ig superfamily members are known to mediate cell adhesion, or antigen recognition, e.g. immunoglobulins, T-cell receptors, and MHC molecules. In addition, a subgroup comprising 30 members characterized by the presence of one or more immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within their cytoplasmic domain has also been recognized. CD31, which has 6 ITIMs within its cytoplasmic domain, is a member of this subfamily.


Recommended Products

252252 CD31 (N-term) Antibody, HRP
252266 CD31 (N-term) Antibody, FITC

Alternate Names

Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; CPIIA'; CD31 antigen; PECAM1

Accession No.

P16284

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CD31.

Application Notes

E: 1:500-1:1,000

WB: 1:200-1:500

IHC: 1:200-1:500

 

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Cell Adhesion Molecules,  CAM Ligands,  Cellular Antigens,  Enzymes,  Glycan Binding Proteins,  Receptors and Channels,  Immune System, Signaling Molecules & Interaction

For research use only, not for diagnostic or therapeutic procedures.