CD41/GPIIa Antibody

Catalog Number

250176

Unit

0.1 mg

Price

$245.00

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Data and Images

Description

This antibody recognizes the CD41 antigen within the CD41/CD61 heterodimer (also called integrin IIbIIIa), which is expressed on platelets and megakaryocytes. The CD41/CD61 cell surface protein is the receptor for fibrinogen, fibronectin and von Willebrand factor and mediates platelet adhesion and aggregation. The antibody can be used for detecting CD41 in flow cytometry and immunoprecipitation.

Product Citations

McMichael, AJ et al. (eds), Leukocyte typing III., Oxford University Press, Oxford (1987)

Recommended Products

Alternate Names

Integrin alpha-IIb; Platelet membrane glycoprotein IIb; GPalpha IIb; GPIIb; CD41 antigen; ITGA2B; GP2B; ITGAB

Accession No.

P08514
NP_000410

Clonality

96.2C1

Antigen

Application Notes

FACS with whole blood: 100 μl blood + 10 μl antibody

FACS with cells: 500,000 cells in 50 μl + 10 μl antibody

FACS with platelets: 5 μl blood + 5 μl antibody, add 1 ml 1% paraformaldehyde after 15 min, no wash needed. Platelets must be stained within 10 min of blood collection.

This antibody recognizes the CD41 antigen in the CD41/CD61 complex. In flow cytometry, the antibody stains >90% of human peripheral blood platelets.

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.