ER-beta (N-term) Antibody

Catalog Number

251152

Unit

0.1 mg

Price

$245.00

Isotype

Applications

Species reactivity

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Description

Estrogen receptor beta (ER-beta) is a nuclear hormone receptor. ER-beta binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. ER-beta binds DNA as a homodimer, and can form a heterodimer with ESR1. ER-beta interacts with NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes.

Alternate Names

Estrogen receptor; ER; Estrogen receptor-beta; Estrogen receptor beta; Nuclear receptor subfamily 3 group A member 2; ESR2; ESTRB

Accession No.

Q92731

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human ER-beta.

Application Notes

E: 1:500-1:1,000
WB: 1:100-1:500
IHC: 1:100-1:500

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.