Factor I Antibody

Catalog Number

250120

Unit

0.1 mg

Price

$245.00

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Data and Images

Description

The complement factor I is responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively. These protein cleavages inactivate complement components C3b, iC3b and C4b. Factor I consists of a heterodimer of a light and heavy chains linked by disulfide bonds. Factor I deficiencies (CFI) result in increasing risks for pyrogenic infections, such as hemolytic uraemic syndrome (HUS), an acute renal failure in childhood due to E. coli infection. This antibody recognizes human complement factor I in ELISA.

Product Citations

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Alternate Names

Complement factor I; C3B/C4B inactivator; Factor I heavy chain; Factor I light chain; CFI; IF

Accession No.

P05156
NP_000195

Clonality

KT22

Antigen

Purified human complement factor I protein

Application Notes

E: 5 μg/ml

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.