Mitofusin-2 Antibody

Rabbit Polyclonal

Catalog Number

251872

Unit

0.1 mg

Price

$245.00

Isotype

Rabbit Ig

Applications

E, WB, IHC

Species reactivity

H, M, R

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 5% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.

Data and Images

Cat. No. 251872: The Antibody is used in Western blot to detect mitofusin-2 in rat cardiac muscle.Cat. No. 251872: The Mitofusin-2 Antibody is used in Western blot to detect mitofusin-2 in rat cardiac muscle.

Description

Mitofusin-2 is as essential transmembrane GTPase which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. Mitofusin-2 acts independently of the cytoskeleton, plays a central role in mitochondrial metabolism, and is associated with obesity and/or apoptosis processes. Defects in mitofusin-2 are the cause of Charcot-Marie-Tooth disease type 2A2 (CMT2A2). CMT2A2 is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system.


Alternate Names

Mitofusin-2; Transmembrane GTPase MFN2; MFN2; CPRP1; KIAA0214

Accession No.

O95140

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human mitofusin-2.

Application Notes

E: 1:500-1:1,000
WB: 1:100-1:500

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Enzymes,  GTP-binding Proteins,  Neurodegenerative Disorders

For research use only, not for diagnostic or therapeutic procedures.