MMP-2 Antibody

Catalog Number

250752

Unit

0.1 mg

Price

$231.00

Isotype

Applications

Species reactivity

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Data and Images

Description

Matrix metalloproteinase protein family (MMP) is involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic development, reproduction, and tissue remodeling, as well as in diseases such as arthritis and metastasis. Most MMPs are secreted as inactive precursors which are activated upon cleavage by extracellular proteinases. MMP-2 is an enzyme that degrades gelatin type I and collagen types IV, V, VII and X, and KiSS1. MMP-2 is also a ligand for the integrin alpha-V/beta-3. Defects in MMP-2 are the cause of multicentric osteolysis nodulosis and arthropathy (MONA), and Winchester syndrome, both characterized by excessive destruction and resorption of bones.

Product Citations

Li X et al. 2011. Medical Oncology. doi: 10.1007/s12032-11-9904-1

Riau A et al. PLoS One. 2011. 6(2): e14687. doi:10.1371/journal.pone.0014687

Seet L et al. PLoS One. 2010. 5(2): e9415

Alternate Names

72 kDa type IV collagenase; 72 kDa gelatinase; Matrix metalloproteinase-2; MMP-2; Gelatinase A; TBE-1; MMP2; CLG4A

Accession No.

P08253

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human MMP-2.

Application Notes

E: 1:500-1:1,000

WB: 1:200-1:500

IHC: 1:200-1:500

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.