PAPP-A (1_1) Antibody

Catalog Number

250219

Unit

0.2 mg

Price

$545.00

Format

Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.

Data and Images

Description

Pregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease, PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein of approximately 500 kDa, which was first discovered in serum from pregnant women. The heterotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Down’s syndrome (trisomy 21). This antibody is specific for native human PAPP-A.

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Alternate Names

<p> Pregnancy-associated plasma protein A; Pappalysin-1(precursor); Insulin-like growth factor-dependent IGF-binding protein 4 protease; IGF-dependent IGFBP-4 protease; IGFBP-4ase </p>

Accession No.

Q13219

Clonality

1_1

Antigen

Purified human PAPP-A

Application Notes

Product Cat. No. 250219 only detects unreduced PAPP-A in Western Blotting. In a sandwich ELISA with a polyclonal antibody used as a capture reagent, Product Cat. No. 250219 reacts poorly with PAPP-A in third trimester serum. 

E: 1:20;

WB: 1:1,000;

IHC: 1:200

Storage

Store at 4°C. Product is guaranteed 6 months from the date of shipment.