Slicer Antibody

Catalog Number

200187

Unit

0.1 mg

Price

$220.00

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Data and Images

Description

Eukaryotic translation initiation factor 2C 2, also known as Slicer protein or Argonaute-2, provides endonuclease activity to RNA-induced silencing complexes (RISC). Slicer cleaves siRNA/mRNA heteroduplexes bound to RISC. Slicer is essential for embryonic development and RNA-mediated gene silencing (RNAi). Slicer is localised in processing bodies (P bodies) that contain decapping enzymes, a 5'-to-3' exoribonuclease, LSm proteins, and RNAi machinery components.

Product Citations

Recommended Products

Alternate Names

Eukaryotic translation initiation factor 2C 2; elF2C 2; elF-2C 2; Argonaute-2; Slicer protein; PAZ Piwi domain protein; PPD; ElF2C2; AGO2

Accession No.

Q9UKV8
NP_036286

Clonality

ABT-1091

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Slicer.

Application Notes

E: 1:500-1:1,000

WB: 1:100-1:500

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.