Thioguanine (6F7) Antibody

Catalog Number

250363

Unit

0.2 mg

Price

$545.00

Format

Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.

Data and Images

Description

Thioguanine is a purine analogue used in cancer chemotherapy. It is the 6-thione analogue of the endogenous 6-OH purine base guanine. In the cell thioguanine is converted to the ribonucleotides: 6-thioguanosine-5'-phosphate and 6-thioinosine-5'-phosphate. These fraudulent nucleotides produce their cytotoxic effects by several mechanisms, e.g. inhibitory action on de novo purine synthesis, and may themselves be incorporated into DNA. Thioguanine has a molecular weight of 167 Da. This antibody is specific for thioguanine. Cross-reactivity is seen with a variety of thioguanine analogs except for 6-thioxanthine and 2-amino-6-(methylthio)purine.

Product Citations

Recommended Products

Alternate Names

HGPRT;  HGPRTase

Accession No.

P00492

Clonality

6F7

Antigen

7-substituted thioguanine linked to PPD (2)

Application Notes

Product Cat. No. 250363 reacts strongly with free thioguanine. Antibody binding is primarily dependent on the structure of the pyrimidine ring.

E: 1:2,000

Storage

Store at 4°C. Product is guaranteed 6 months from the date of shipment.