TNF-R2 Antibody

Catalog Number

250107

Unit

0.1 mg

Price

$245.00

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Data and Images

Description

Tumor necrosis factor receptor 2 (TNF-R2) is a high-affinity receptor for TNF-alpha and a low-affinity receptor for lymphotoxin-alpha. TNF-R2 has two isoforms produced by alternative splicing: a cell membrane and a secreted form. The latter blocks TNF-alpha-induced apoptosis, which suggests that this isoform regulates TNF-alpha function by antagonizing its biological activity. A soluble fragment of TNF-R2 (Enbrel, Immunex and Wyeth-Ayerst) is used as treatment of moderate and severe rheumatoid arthritis. This antibody recognizes human TNF-R2 in ELISA and flow cytometry.

Product Citations

Recommended Products

250108 TNF-alpha Antibody

Alternate Names

Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; p75; p80 TNF-alpha receptor; CD120b antigen; Etanercept; Tumor necrosis factor-binding protein 2; TNFRSF1B; TNFBR, TNFR2

Accession No.

P20333
NP_001057

Clonality

KT30

Antigen

Recombinant soluble human TNF-R2-Fc fusion protein

Application Notes

E: 5 μg/ml

FACS: 1 μg/0.1 ml

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.