Calcineurin Autoinhibitory Peptide

Inhibitory Peptide

Synthetic Peptide

Cat. No.

350004

Unit

1 mg

Price $179.00

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Abbiotec

7985 Dunbrook Rd., Ste A
San Diego, CA 92126, USA

Phone: 1 858 586 0500,
1 800 854 7453

Fax: 1 858 586 6252

Email: info@abbiotec.com

Website: http://www.abbiotec.com

Description

This peptide is a specific inhibitor for calcineurin (PP2BA), a Ser/Thr protein phosphatase from the PPP family and PP2B subfamily. The peptide corresponds to the residues 467-491 within the inhibitory domain of human calcineurin alpha subunit. Calcineurin is known to dephosphorylate heat shock protein beta-1 (HSPB1) and protein phosphatase Slingshot homolog 1 (SSH1). This peptide inhibits Mn2+-stimulated calcineurin activity (IC50 = 10 uM using 32P-myosin light chain as substrate) but has no effect on Ni2+-stimulated enzyme activity. It does not inhibit CaMKII kinase, protein phosphatase 1 or 2A.

Spec Container

Datasheet

Format

Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.

Alternate Names

Serine/Threonine-protein phosphatase 2B catalytic subunit alpha isoform; Calmodulin-dependent calcineurin A subunit alpha isoform; CAM-PRP catalytic subunit; PPP3CA; CALNA; CAN

Accession No.

Q08209

2930.4 g/mol

Sequence

Ile-Thr-Ser-Phe-Glu-Glu-Ala-Lys-Gly-Leu-Asp-Arg-Ile-Asn-Glu-Arg-Met-Pro-Pro-Arg-Arg-Asp-Ala-Met-Pro or ITSFEEAKGLDRINERMPPRRDAMP

Composition

C124H205N39O39S2

Purity

Purity > 95% by HPLC

Solubility

Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Storage

Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.

Related Products

Antibody Products
Product Name	Applications	SKU	Price
Calcineurin Antibody	E, WB, IHC	251715	$245.00
PP-2B alpha 1 Antibody	E, WB, IHC	250832	$231.00
RCAN2 Antibody	E, WB, IHC	254029	$310.00

Peptide Products
Product Name	Applications	SKU	Price
Calcineurin Substrate Peptide		350105	$180.00

Lysate Products
Product Name	Applications	SKU	Price
CHP 293 Cell Lysate	ELISA, WB, IP	401872	$392.00
MYOZ2 293 Cell Lysate	ELISA, WB, IP	402247	$392.00
NFAM1 293 Cell Lysate	ELISA, WB, IP	402987	$392.00
PPP3CC 293 Cell Lysate	ELISA, WB, IP	401543	$392.00
PPP3R1 293 Cell Lysate	ELISA, WB, IP	410100	$392.00
PPP3R2 293 Cell Lysate	ELISA, WB, IP	404368	$392.00
RCAN3 293 Cell Lysate	ELISA, WB, IP	407323	$392.00

For research use only, not for diagnostic or therapeutic procedures.

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Calcineurin Autoinhibitory Peptide

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