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BRCA1 Peptide
Catalog Number350522 Unit0.1 mg Price$50.00 |
Description
Breast cancer type 1 susceptibility protein (BRCA1) plays a central role in DNA repair by facilitating cellular response to DNA repair. BRCA1 is required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. BRCA1 is part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. Defects in BRCA1 are a cause of genetic susceptibility to breast and ovarian cancers.
FormatEach vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect. Data and Images |
Product CitationsRecommended ProductsAlternate NamesBreast cancer type 1 susceptibility protein; RING finger protein 53; BRCA1; RNF53 Accession No.MW2141.3 g/mol SequenceThe synthetic peptide used to raise the antibody Cat. No. 200160 is selected from a sequence within the N-term region of human BRCA1. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended. CompositionC88H149N29O31S1 PurityPurity > 80% by HPLC SolubilityDistilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile. StorageStore at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C. |
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For research use only, not for diagnostic or therapeutic procedures.