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FANCL Peptide
Catalog Number350524 Unit0.1 mg Price$50.00 |
Description
Fanconi anemia group L protein (FANCL) is an ubiquitin ligase that mediates ubiquitination of FANCD2, a key step in the DNA damage pathway. FANCL is required for proper primordial germ cell proliferation in the embryonic stage. Defects in FANCA are the cause of Fanconi anemia, a syndrome characterized by pancytopenia, congenital malformations and predisposition to cancers caused by a hypersensitivity to DNA-damaging agents, chromosomal instability and defective DNA repair.
FormatEach vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect. Data and Images |
Product CitationsRecommended ProductsAlternate NamesE3 ubiquitin-protein ligase FANCL; Fanconi anemia group L protein; Fanconi anemia-associated polypeptide of 43 kDa; FAAP43; FANCL; PHF9 Accession No.MW2031.2 g/mol SequenceThe synthetic peptide used to raise the antibody Cat. No. 200162 is selected from a sequence within the N-term region of human FANCL. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended. CompositionC85H135N27O29S1 PurityPurity > 80% by HPLC SolubilityDistilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile. StorageStore at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C. |
For research use only, not for diagnostic or therapeutic procedures.