FANCL Peptide

Catalog Number

350524

Unit

0.1 mg

Price

$50.00

Description

Fanconi anemia group L protein (FANCL) is an ubiquitin ligase that mediates ubiquitination of FANCD2, a key step in the DNA damage pathway. FANCL is required for proper primordial germ cell proliferation in the embryonic stage. Defects in FANCA are the cause of Fanconi anemia, a syndrome characterized by pancytopenia, congenital malformations and predisposition to cancers caused by a hypersensitivity to DNA-damaging agents, chromosomal instability and defective DNA repair.

Format

Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.

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200162 FANCL Antibody

Alternate Names

E3 ubiquitin-protein ligase FANCL; Fanconi anemia group L protein; Fanconi anemia-associated polypeptide of 43 kDa; FAAP43; FANCL; PHF9

Accession No.

Q9NW38
NP_060532

MW

2031.2 g/mol

Sequence

The synthetic peptide used to raise the antibody Cat. No. 200162 is selected from a sequence within the N-term region of human FANCL. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.

Composition

C85H135N27O29S1

Purity

Purity > 80% by HPLC

Solubility

Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Storage

Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.

For research use only, not for diagnostic or therapeutic procedures.