Matrix metalloproteinase protein family (MMP) is involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic development, reproduction, and tissue remodeling, as well as in diseases such as arthritis and metastasis. Most MMPs are secreted as inactive precursors which are activated upon cleavage by extracellular proteinases. MMP-2 is an enzyme that degrades gelatin type I and collagen types IV, V, VII and X, and KiSS1. MMP-2 is also a ligand for the integrin alpha-V/beta-3.
Matrix metalloproteinase family members are involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic development, reproduction and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Matrix metalloproteinase-1 (Interstitial collagenase A/B or MMP-1) cleaves collagens of types I, II and III. This antibody is specific for mouse MMP-1.
Fibroblast growth factor 7 (FGF-7 or keratinocyte growth factor) is a growth factor active on keratinocytes. FGF-7 is a major paracrine effector of normal epithelial cell proliferation.
Hematopoietic progenitor cell antigen CD34 is a leukocyte antigen expressed in various cell types including hematopoietic cells. Antibodies against CD34 are used to identify lymphohematopoietic stem/progenitor cells. CD34 is likely an adhesion molecule with a role in early hematopoiesis by mediating attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells.
CD31 (PECAM1) is a member of the immunoglobulin (Ig) superfamily that is expressed on the surface of circulating platelets, monocytes, neutrophils, and particular T-cell subsets. CD31 is also a major constituent of the endothelial cell intercellular junction, where up to an estimated 1 million molecules are concentrated. Because of this cellular expression pattern, CD31 is implicated in several functions, including transendothelial migration of leukocytes, angiogenesis, and integrin activation. Ig superfamily members are known to mediate cell adhesion, or antigen recognition, e.g.