CAM Ligands

Human fibroblast growth factor 22 (FGF-22) is a member of the FGF-7 subfamily of growth factors. Human FGF-22 shares 86% homology to Mouse FGF-22, and is synthesized by multiple cell lines including neurons, keratinocytes and skeletal muscle myotubes. It is believed to function as an organizer of the presynaptic apparatus. Recombinant Human FGF-22 is a nonglycosylated polypeptide protein consisting of 149 amino acids with a MW of 17.3 kDa.

Human endocrine gland derived vascular endothelial growth factor (EG-VEGF) is selectively expressed in steroidogenic glands and promotes growth of endocrine gland endothelium. The identification of tissue-selective angiogenic factors raises the possibility that other secreted molecules in this class exist. Consistent with such an expression pattern, the human EG-VEGF gene promoter has a potential binding site for steroidogenic factor SF-1, a pivotal element for steroidogenic-specific transcription.

Vascular Cell Adhesion Molecule-1 (VCAM-1) is a cell surface sialoglycoprotein expressed by cytokine activated endothelium. The protein has a number of functions including the regulation of leukocyte migration, leukocyte-endothelial cell adhesion and signal transduction, and plays a role in a number of inflammatory diseases. Recombinant VCAM-1 comprises a 674 amino acid fragment (25-698) corresponding to the mature extracellular VCAM-1 protein and is expressed in E. coli with an amino-terminal hexahistidine tag.

Vascular Cell Adhesion Molecule-1 (VCAM-1) is a cell surface sialoglycoprotein expressed by cytokine activated endothelium. The protein has a number of functions including the regulation of leukocyte migration, leukocyte-endothelial cell adhesion and signal transduction, and plays a role in a number of inflammatory diseases. Recombinant VCAM-1 [109-331] comprises a 203 amino acid fragment (109-331) corresponding to the Ig-like C2 type domains 2 and 3 and is expressed in E. coli with an amino-terminal hexahistidine tag.

Transforming growth factor beta-1 (TGF beta 1) is a member of the larger TGF beta superfamily of cytokines produced by a wide variety of cells that are involved in the regulation of cell proliferation, differentiation, apoptosis, cellular homeostasis and a wide variety of other cellular functions. TGF beta 1 has been shown to regulate the actions of many other growth factors involved in a range of human diseases including renal disease, hepatic disease, heart failure and cardiomyopathies.