Human fibroblast growth factor 22 (FGF-22) is a member of the FGF-7 subfamily of growth factors. Human FGF-22 shares 86% homology to Mouse FGF-22, and is synthesized by multiple cell lines including neurons, keratinocytes and skeletal muscle myotubes. It is believed to function as an organizer of the presynaptic apparatus. Recombinant Human FGF-22 is a nonglycosylated polypeptide protein consisting of 149 amino acids with a MW of 17.3 kDa.
Fibroblast growth factor 21 (FGF-21) is a member of the heparin-binding growth factors family. FGF-21 stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression. Recombinant Human FGF-21 produced in E. coli is a single non-glycosylated polypeptide chain containing 182 amino acids with a MW of 19.5 kDa.
Human endocrine gland derived vascular endothelial growth factor (EG-VEGF) is selectively expressed in steroidogenic glands and promotes growth of endocrine gland endothelium. The identification of tissue-selective angiogenic factors raises the possibility that other secreted molecules in this class exist. Consistent with such an expression pattern, the human EG-VEGF gene promoter has a potential binding site for steroidogenic factor SF-1, a pivotal element for steroidogenic-specific transcription.
Connective tissue growth factor (CTGF) belongs to the CCN family of secreted proteins. CTGF is a member of cysteine rich regulatory proteins playing an important role in mitogenic and chemotaxis. Each protein has an IGF-binding domain, a thrombospondin type 1 domain and cysteine knot region. CTGF has multiple effects on development and differentiation. H-CTGF is comprised of 98 amino acids with a molecular weight of 11.2 kDa.
Vascular Cell Adhesion Molecule-1 (VCAM-1) is a cell surface sialoglycoprotein expressed by cytokine activated endothelium. The protein has a number of functions including the regulation of leukocyte migration, leukocyte-endothelial cell adhesion and signal transduction, and plays a role in a number of inflammatory diseases. Recombinant VCAM-1 comprises a 674 amino acid fragment (25-698) corresponding to the mature extracellular VCAM-1 protein and is expressed in E. coli with an amino-terminal hexahistidine tag.
Vascular Endothelial Growth Factor (VEGF) is a heparin-binding glycoprotein which can exist in a number of different isoforms. The protein has been found to be a potent inducer of angiogeneis and endothelial cell proliferation, and plays an important role in regulating vasculogenesis. VEGF can be detected in both the plasma and serum and has been implicated in several disease states associated with augmented angiogenesis. Recombinant VEGF-165 comprises a 165 amino acid fragment (5-169) corresponding to the VEGF 165 isoform and is expressed in E.
Vascular Cell Adhesion Molecule-1 (VCAM-1) is a cell surface sialoglycoprotein expressed by cytokine activated endothelium. The protein has a number of functions including the regulation of leukocyte migration, leukocyte-endothelial cell adhesion and signal transduction, and plays a role in a number of inflammatory diseases. Recombinant VCAM-1 [109-331] comprises a 203 amino acid fragment (109-331) corresponding to the Ig-like C2 type domains 2 and 3 and is expressed in E. coli with an amino-terminal hexahistidine tag.
Tumour necrosis factor alpha (TNF alpha) is a potent pleiotrophic cytokine produced by white blood cells, endothelium, and several other normal and tumour cells in response to a wide variety of stimuli. TNF alpha is involved in the pathophysiological processes of several chronic and acute diseases, including the induction of apoptosis and up regulation of inflammation. Recombinant TNF alpha comprises a 157 amino acid fragment (77-233) corresponding to the mature soluble TNF alpha chain protein. TNF alpha is expressed in E. coli with an amino-terminal hexahistidine tag.
Transforming growth factor beta-1 (TGF beta 1) is a member of the larger TGF beta superfamily of cytokines produced by a wide variety of cells that are involved in the regulation of cell proliferation, differentiation, apoptosis, cellular homeostasis and a wide variety of other cellular functions. TGF beta 1 has been shown to regulate the actions of many other growth factors involved in a range of human diseases including renal disease, hepatic disease, heart failure and cardiomyopathies.
P-selectin belongs to a family of divalent cation dependent carbohydrate-binding glycoproteins or adhesion molecules. P-selectin is expressed transiently on the surface of activated platelets and endothelial cells. Secreted P-selectin is thought to play a key role in the adhesion of platelets to monocytes and neutrophils during an inflammatory response. Levels of P-selectin may be elevated in a number of pathological conditions.