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CAM Ligands

VEGF-A Antibody

$245.00
SKU: 251675
VEGF-A (Vascular endothelial growth factor A) is a growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. VEGF-A induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. VEGF-A binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate, and heparin.
VEGF-A staining in rat brain. Paraffin-embedded rat brain is stained with VEGF-A Antibody (Cat. No. 251675) used at 1:200 dilution.
List price: $0.00
Price: $245.00

CD40L Antibody

$245.00
SKU: 251649
CD40L mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4, and is involved in immunoglobulin class switching. Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway. Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1, also known as X-linked hyper IgM syndrome (XHIM).
CD40L staining in human stomach. Paraffin-embedded human stomach tissue is stained with CD40L Antibody (Cat. No. 251649) used at 1:200 dilution.
List price: $0.00
Price: $245.00

HLA-DR Antibody

$245.00
SKU: 251566
HLA class II histocompatibility antigen (HLA-DR) binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by CD4 T-cells. HLA-DR is a heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. The peptides presented by HLA-DR and other MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases.
HLA-DR staining in lung cancer: Paraffin-embedded human lung cancer tissue is stained with HLA-DR Antibody (Cat. No. 251566) used at 1:200 dilution.
List price: $0.00
Price: $245.00

CD152 Antibody

$245.00
SKU: 251548
CD152 antigen (Cytotoxic T-lymphocyte protein 4, CTLA-4) binds to B7-1 (CD80 antigen) and B7-2 (CD86 antigen), resulting in T-cell activation. Genetic variation in CD152 influences susceptibility to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. SLE affects principally the skin, joints, kidneys and serosal membranes. SLE is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
CD152 staining in mouse placenta. Paraffin-embedded mouse placenta is stained with CD152 Antibody (Cat. No. 251548) used at 1:200 dilution.
List price: $0.00
Price: $245.00

Laminin alpha-5 Antibody

$245.00
SKU: 251457
Laminin subunit alpha-5 is a complex glycoprotein, major part of the basal lamina. Laminins are consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-5 is a subunit of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). Laminin 5 mediates the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Laminin alpha-5 staining of rat kidney. Paraffin-embedded rat kidney tissue is stained with Laminin alpha-5 Antibody (Cat. No. 251457) used at 1:200 dilution.
List price: $0.00
Price: $245.00

CD11b Antibody

$245.00
SKU: 251389

CD11b is involved in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. CD11b is identical with CR-3, the receptor for the iC3b fragment of the third complement component. Genetic variations in CD11b have been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6). SLEB6 is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes.

The CD11b Antibody is used in Western blot to detect CDllb in mouse liver lysates.
List price: $0.00
Price: $245.00

CD144 Antibody

$245.00
SKU: 251361
CD144 belongs to the cadherin family of proteins, which are calcium dependent cell adhesion proteins. CD144 plays an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. CD144 associates with alpha-catenin forming a link to the cytoskeleton.
CD144 staining in human brain. Paraffin-embedded human brain tissue is stained with CD144 Antibody (Cat. No. 251361) used at a 1:200 dilution.
List price: $0.00
Price: $245.00

Siglec-1 Antibody

$245.00
SKU: 251297
Sialic acid-binding Ig-like lectin 1 (siglec-1) acts as an endocytic receptor mediating clathrin- dependent endocytosis. Siglec-1 mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells.
Siglec-1 staining of rat kidney. Paraffin-embedded rat kidney tissue is stained with Siglec-1 Antibody (Cat. No. 251297) used at 1:200 dilution.
List price: $0.00
Price: $245.00

CTGF Antibody

$245.00
SKU: 251261
Connective tissue growth factor (CTGF) is a major connective tissue mitoattractant secreted by vascular endothelial cells. CTGF promotes proliferation and differentiation of chondrocytes. CTGF mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. CTGF enhances fibroblast growth factor-induced DNA synthesis.
CTGF staining in rat kidney. Paraffin-embedded rat kidney tissue is stained with CTGF Antibody (Cat. No. 251261) used at 1:200 dilution.
List price: $0.00
Price: $245.00

CD45 Antibody

$245.00
SKU: 251175

The CD45 antigen (Receptor-type tyrosine-protein phosphatase C, PTPRC) is a protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. CD45 acts as a positive regulator of T-cell coactivation upon binding to DPP4. Defects in CD45 are a cause of severe combined immunodefiency autosomal recessive T-cell negative/B-cell-positive/NK-cell-positive (T-B+NK+ SCID). Genetic variations in CD45 are involved in multiple sclerosis susceptibility.

CD45 staining in rat ovary. Paraffin-embedded rat ovary is stained with CD45 Antibody (Cat. No. 251175) used at 1:200 dilution.
List price: $0.00
Price: $245.00

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