Cytokines

Basic fibroblast growth factor (bFGF or Heparin-binding growth factor 2) is a single-chain polypeptide growth factor that plays a significant role in the process of wound healing and is a potent inducer of angiogenesis. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor. Recombinant Human FGF-b (FGF-2) isoform 147 produced in E.

Human fibroblast growth factor 22 (FGF-22) is a member of the FGF-7 subfamily of growth factors. Human FGF-22 shares 86% homology to Mouse FGF-22, and is synthesized by multiple cell lines including neurons, keratinocytes and skeletal muscle myotubes. It is believed to function as an organizer of the presynaptic apparatus. Recombinant Human FGF-22 is a nonglycosylated polypeptide protein consisting of 149 amino acids with a MW of 17.3 kDa.

Human endocrine gland derived vascular endothelial growth factor (EG-VEGF) is selectively expressed in steroidogenic glands and promotes growth of endocrine gland endothelium. The identification of tissue-selective angiogenic factors raises the possibility that other secreted molecules in this class exist. Consistent with such an expression pattern, the human EG-VEGF gene promoter has a potential binding site for steroidogenic factor SF-1, a pivotal element for steroidogenic-specific transcription.

Ciliary neurotrophic factor (CNTF) is a neurotrophic factor that promotes the survival of various neuronal cell types and may play an important role in the injury response in the nervous system. CNTF, like FGF acidic, FGF basic, and PD-ECGF (platelet-derived endothelial cell growth factor ), does not possess a signal sequence that would allow secretion of the factor by classical secretion pathways (endoplasmatic reticulum/Golgi system). The mechanism underlying the release of CNTF is unknown. Recombinant Human CNTF produced in E.

Tumor necrosis factor beta (TNF beta) is a potent multifunctional cytokine produced mainly by activated T and B lymphocytes. The protein has been shown to have a specific potent cytotoxic activity on tumor cells and a variety of other target cells. TNF beta is also a mediator of inflammation and immune functions. Recombinant TNF beta comprises a 171 amino acid fragment (35-205) corresponding to the mature TNF beta chain protein and is expressed in E.