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Cytoskeleton Proteins

Myosin (smooth) Antibody

$245.00
SKU: 251772
Myosin is a hexameric protein involved in muscle contraction, which consists of two heavy chains (200kDa), and four light chains (20kDa): two phosphorylated regulatory subunits (MLC2) and two non-phosphorylated subunits (alkali or MLC1 and MLC3 types). Myosin (smooth) (myosin heavy chain, smooth muscle isoform, also called MYH11) is mapped to the region 16p13.13-p13.12. Defects in MYH11 are the cause of familial aortic aneurysm thoracic type 4 (AAT4 or TAAD).
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Price: $245.00

Myosin (slow) Antibody

$245.00
SKU: 251771
Myosin is a hexameric protein involved in muscle contraction, which consists of two heavy chains (200kDa), and four light chains (20kDa): two phosphorylated regulatory subunits (MLC2) and two non-phosphorylated subunits (alkali or MLC1 and MLC3 types). Myosin (slow) (myosin light chain 1, slow-twitch muscle B/ventricular isoform, also called MYL3) is mapped to the region 3p. Defects in MYL3 are the cause of familial hypertrophic cardiomyopathy type 8 (CMH8).
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Price: $245.00

Spectrin alpha/beta Antibody

$245.00
SKU: 251797
Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. Spectrin associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Defects in spectrin are the cause of elliptocytosis type 2 (EL2). EL2 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. EL2 is characterized by variable hemolytic anemia and elliptical or oval red cell shape.
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Price: $245.00

Cytokeratin-13 Antibody

$245.00
SKU: 251732

***DISCONTINUED***

Keratin, type I cytoskeletal 13 (cytokeratin-13) is a type I cytokeratin. Cytokeratin 1 is paired with keratin 4 and found in the suprabasal layers of non-cornified stratified epithelia. Mutations in the gene encoding cytokeratin-13 and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus (WSN). WSN is a rare autosomal dominant disorder which predominantly affects non-cornified stratified squamous epithelia. Clinically, WSN is characterized by the presence of soft, white, and spongy plaques in the oral mucosa.

List price: $0.00
Price: $245.00

Myosin (fast) Antibody

$245.00
SKU: 251770
Myosin is a hexameric protein involved in muscle contraction, which consists of two heavy chains (200kDa), and four light chains (20kDa): two phosphorylated regulatory subunits (MLC2) and two non-phosphorylated subunits (alkali or MLC1 and MLC3 types). Myosin (fast) (myosin light chain 1/3, skeletal muscle isoform, also called MYL1) is mapped to the region 2q32.1-qter.
List price: $0.00
Price: $245.00

Gelsolin Antibody

$245.00
SKU: 251751
Gelsolin is a calcium-regulated, actin-modulating protein that binds to the plus ends of actin monomers and filaments, preventing monomer exchange. Gelsolin promotes the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Defects in gelsolin are the cause of amyloidosis type 5 (AMYL5), also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition, and is typically characterized by cranial neuropathy and lattice corneal dystrophy.
List price: $0.00
Price: $245.00

Filensin Antibody

$245.00
SKU: 251748
Beaded filament structural protein 1 (filensin) is a lens-specific intermediate filament-like protein. Filensin is expressed only after fiber cell differentiation has begun. Filensin is found in a structurally unique cytoskeletal element that is referred to as the beaded filament (BF).
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Price: $245.00

Elastin Antibody

$245.00
SKU: 251745
Elastin (ELN, tropoelastin) is a major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. A molecular determinant of the late arterial morphogenesis, elastin stabilizes arterial structure by regulating proliferation and organization of vascular smooth muscle.
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Price: $245.00

Dystrophin Antibody

$245.00
SKU: 251744
Dystrophin anchors the extracellular matrix to the cytoskeleton via F-actin. Dystrophin is the ligand for dystroglycan. Dystrophin is a component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma.Defects in DMD are the cause of Duchenne muscular dystrophy (DMD). DMD is the most common form of muscular dystrophy; a sex-linked recessive disorder.
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Price: $245.00

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