Xeroderma pigmentosum group C-complementing protein (XPC) is involved in DNA excision repair by recognizing DNA damage and altering chromatin structure for damage-processing enzymes. Defects in XPC are a cause of xeroderma pigmentosum complementation group C characterized by solar sensitivity and skin cancer predisposition.
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Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Pathway and Disease
Replication and Repair
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
DNA-repair protein complementing XP-C cells; Xeroderma pigmentosum group C-complementing protein; p125; XPC; XPCC
The synthetic peptide used to raise the antibody Cat. No. 200169 is selected from a sequence within the C-term region of human XPC. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity > 80% by HPLC
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Monday, December 17, 2012