Glycan Binding Proteins
L-Selectin Peptide
KAL1 293 Cell Lysate

Human Galectin-3
Recombinant Human Galectin-3 is a member of a large family of carbohydrate-binding proteins. Also known as Mac-2, L29and CBP35, Human Galectin-3 is expressed by a wide range of cell types including activated T-cells, tumor cells, macrophages, osteoclasts, fibroblasts and epithelial cells. Galectin-3 exhibits proinflammatory activities both in vitro and in vivo. Galectin-3 also chemoattracts monocytes and macrophages. Increased circulating levels of Galectin-3 correlate with several types of cancer, suggesting Galectin-3 is involved in tumor growth and metastasis.
Human VCAM-1
Vascular Cell Adhesion Molecule-1 (VCAM-1) is a cell surface sialoglycoprotein expressed by cytokine activated endothelium. The protein has a number of functions including the regulation of leukocyte migration, leukocyte-endothelial cell adhesion and signal transduction, and plays a role in a number of inflammatory diseases. Recombinant VCAM-1 comprises a 674 amino acid fragment (25-698) corresponding to the mature extracellular VCAM-1 protein and is expressed in E. coli with an amino-terminal hexahistidine tag.
Human VCAM-1 [109-331]
Vascular Cell Adhesion Molecule-1 (VCAM-1) is a cell surface sialoglycoprotein expressed by cytokine activated endothelium. The protein has a number of functions including the regulation of leukocyte migration, leukocyte-endothelial cell adhesion and signal transduction, and plays a role in a number of inflammatory diseases. Recombinant VCAM-1 [109-331] comprises a 203 amino acid fragment (109-331) corresponding to the Ig-like C2 type domains 2 and 3 and is expressed in E. coli with an amino-terminal hexahistidine tag.
Human L-Selectin
L-Selectin belongs to a family of divalent cation dependent carbohydrate-binding glycoproteins or adhesion molecules. L-Selectin is expressed constitutively on lymphocytes, monocytes and granulocytes and interacts specifically with carbohydrate groups on activated endothelial cells. L-Selectin is shed by proteolytic cleavage and circulating levels in biological fluids are used as an indicator of various pathological conditions. Recombinant human L-selectin comprises a 294 amino acid fragment (39-332) corresponding to the mature L-Selectin extracellular domain and is expressed in E.
Human ICAM-1
Intracellular adhesion molecules (ICAM proteins) are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM-1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. ICAM-1 acts as a cellular receptor for rhinovirus and also interacts with human herpes virus 8 MIR2 protein. Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria.
Human E-Selectin
E-Selectin is a cell-surface glycoprotein which plays role in immunoadhesion. E-Selectin mediates the adhesion of blood neutrophils in cytokine-activated endothelium through interactions with PSGL1/SELPLG. It also plays a role in capillary morphogenesis. Recombinant human E-selectin comprises a 379 amino acid fragment (179-557) corresponding to the cysteine rich complement control region and is expressed in E. coli with an amino-terminal hexahistidine tag.
