Ph. 858 586 0500    Toll Free 800 854 7453

Glycan Binding Proteins

CD62P Peptide

$80.00
SKU: 300105
CD62P (P-Selectin) is a Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. CD62P mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand for CD62P is sialyl-Lewis X. Activation of CD62P mediates leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. Defects in CD62P have been linked to an increased susceptibility to ischemic stroke.
List price: $0.00
Storage 
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Price: $80.00
Protein Family 
CAM Ligands
Glycan Binding Proteins
Pathway and Disease 
Signaling Molecules and Interaction
Infectious Diseases
Format 
Each vial contains 0.1 ml peptide in deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
Alternate Names 
CD62P; P-selectin; Granule membrane protein 140; GMP-140; PADGEM; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; CD62 antigen-like family member P; SELP
Sequence 
The synthetic peptide used to raise the antibody Cat. No. 251211 is selected from a sequence within the N-term region of human CD62P. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity 
Purity > 80% by HPLC
Solubility 
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Release Date 
Monday, December 17, 2012
Subcategory 
Synthetic Peptide
Blocking Peptide
Unit 
0.1 mg
Accession No.  
P16109

L-Selectin Peptide

$88.00
SKU: 350251
Cell surface adhesion molecule. Mediates the adhesion of the Lymphosytes to endothelial cells in peripheral Lymph nodes.
List price: $0.00
Storage 
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.
Price: $88.00
Protein Family 
CAM Ligands
Cell Adhesion Molecules
Cellular Antigens
Glycan Binding Proteins
Pathway and Disease 
Signaling molecules and interaction
Format 
Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.
Alternate Names 
L-selectin; Lymph node homing receptor; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; TQ1; gp90-MEL; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; CD62L antigen; SELL; LNHR; LYAM1
Composition 
C62H105N16O18S2
Sequence 
Human: H-Cys-Gln-Lys-Leu-Asp-Lys-Ser-Phe-Ser-Met-Ile-Lys-OH or H-CQKLDKSFSMIK-OH
Purity 
Purity > 95% by HPLC
Solubility 
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Release Date 
Monday, December 17, 2012
Subcategory 
Synthetic Peptide
MW 
1426.75 g/mol
Unit 
1 mg
Accession No.  
P14151

KAL1 293 Cell Lysate

$672.00
SKU: 400173
Antigen standard for Kallmann syndrome 1 sequence (KAL1) is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid (True ORF cDNA clone RC212305, OriGene Technologies, Inc.) and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection.
List price: $0.00
Image 
KAL1 lysate validation: The KAL1 293 Cell Lysate (lane B) and Control Vector Cell Lysate (lane A) are used in Western blot to detect tagged-KAL1 with a DDK Antibody.
Subcategory 
Cell Lysate
Price: $672.00
Protein Family 
Cell Adhesion Molecules
Glycan Binding Proteins
Pathway and Disease 
Cell Communication
Cell Motility
Development and Behavior
Signaling Molecules and Interaction
ORF Clone URL 
http://www.origene.com/orf_clone/trueclone/accession/NM_000216/RC212305.aspx
Format 
This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol).
Applications 
ELISA
WB
IP
Alternate Names 
Kallmann syndrome-1 sequence (anosmin-1); adhesion molecule-like X-linked; Kallmann syndrome interval gene 1; kallmann syndrome protein; KAL1; ADMLX; HHA; KAL; KALIG-1; KMS
Application Notes 
WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane.
Storage 
Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment.
Release Date 
Thursday, December 13, 2012
Unit 
0.1 mg
Accession No.  
NP_000207

Human Galectin-3

$235.00
SKU: 600117

Recombinant Human Galectin-3 is a member of a large family of carbohydrate-binding proteins. Also known as Mac-2, L29and CBP35, Human Galectin-3 is expressed by a wide range of cell types including activated T-cells, tumor cells, macrophages, osteoclasts, fibroblasts and epithelial cells. Galectin-3 exhibits proinflammatory activities both in vitro and in vivo. Galectin-3 also chemoattracts monocytes and macrophages. Increased circulating levels of Galectin-3 correlate with several types of cancer, suggesting Galectin-3 is involved in tumor growth and metastasis.

List price: $0.00
Price: $235.00

Human VCAM-1

$235.00
SKU: 600308

Vascular Cell Adhesion Molecule-1 (VCAM-1) is a cell surface sialoglycoprotein expressed by cytokine activated endothelium. The protein has a number of functions including the regulation of leukocyte migration, leukocyte-endothelial cell adhesion and signal transduction, and plays a role in a number of inflammatory diseases. Recombinant VCAM-1 comprises a 674 amino acid fragment (25-698) corresponding to the mature extracellular VCAM-1 protein and is expressed in E. coli with an amino-terminal hexahistidine tag.

List price: $0.00
Price: $235.00

Human VCAM-1 [109-331]

$235.00
SKU: 600309

Vascular Cell Adhesion Molecule-1 (VCAM-1) is a cell surface sialoglycoprotein expressed by cytokine activated endothelium. The protein has a number of functions including the regulation of leukocyte migration, leukocyte-endothelial cell adhesion and signal transduction, and plays a role in a number of inflammatory diseases. Recombinant VCAM-1 [109-331] comprises a 203 amino acid fragment (109-331) corresponding to the Ig-like C2 type domains 2 and 3 and is expressed in E. coli with an amino-terminal hexahistidine tag.

List price: $0.00
Price: $235.00

Human L-Selectin

$235.00
SKU: 600273

L-Selectin belongs to a family of divalent cation dependent carbohydrate-binding glycoproteins or adhesion molecules. L-Selectin is expressed constitutively on lymphocytes, monocytes and granulocytes and interacts specifically with carbohydrate groups on activated endothelial cells. L-Selectin is shed by proteolytic cleavage and circulating levels in biological fluids are used as an indicator of various pathological conditions. Recombinant human L-selectin comprises a 294 amino acid fragment (39-332) corresponding to the mature L-Selectin extracellular domain and is expressed in E.

List price: $0.00
Price: $235.00

Human ICAM-1

$235.00
SKU: 600259

Intracellular adhesion molecules (ICAM proteins) are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM-1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. ICAM-1 acts as a cellular receptor for rhinovirus and also interacts with human herpes virus 8 MIR2 protein. Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria.

List price: $0.00
Price: $235.00

Human E-Selectin

$235.00
SKU: 600240

E-Selectin is a cell-surface glycoprotein which plays role in immunoadhesion. E-Selectin mediates the adhesion of blood neutrophils in cytokine-activated endothelium through interactions with PSGL1/SELPLG. It also plays a role in capillary morphogenesis. Recombinant human E-selectin comprises a 379 amino acid fragment (179-557) corresponding to the cysteine rich complement control region and is expressed in E. coli with an amino-terminal hexahistidine tag.

List price: $0.00
Price: $235.00

Human Galectin-1

$235.00
SKU: 600116
Human Galectin-1 belongs to a large family of carbohydrate-binding proteins that contain structural similarities in their carbohydrate recognition domains. Galectin-1, also known as L-14, BHL or galaptin, is a monomer or a homodimer found in a wide varity of cells and tissue types. Galectin-1 controls cell growth and proliferation and induces apoptosis of activated T cells. It can also modulate cytokine secretion or inhibit pro-inflammatory cytokine production. Galectin-1 plays an important role in acute and chronic inflammation.
List price: $0.00
Price: $235.00

Pages

Subscribe to RSS - Glycan Binding Proteins