Hormones

Exendin-4 is a 39-amino-acid peptide found in venom from the Gila monster Heloderma suspectum. It is a member of the glucagon-secretin family of peptide hormones and neuropeptides. Exendin-4 is a potent agonist of the GLP-1 receptor and hence a potent stimulator of insulin secretion. This antibody is specific for exendin-4 with no cross-reactivity with GLP-1, GLP-2 (human) or glucagon coated on ELISA wells.

Exendin-4 is a 39-amino-acid peptide found in venom from the Gila monster Heloderma suspectum. It is a member of the glucagon-secretin family of peptide hormones and neuropeptides. Exendin-4 is a potent agonist of the GLP-1 receptor and hence a potent stimulator of insulin secretion. This antibody is specific for exendin-4 with no cross-reactivity with GLP-1, GLP-2 (human) or glucagon coated on ELISA wells.

Muellerian-inhibiting factor (AMH) is a glycoprotein produced by the Sertoli cells of the testis. AMH causes regression of the Muellerian duct. AMH is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin Defects in AMH are the cause of persistent Muellerian duct syndrome type 1 (PMDS1). PMDS1 is a form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.

Glucagon plays a key role in glucose metabolism and homeostasis. Glucagon regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, glucagon raises plasma glucose levels in response to insulin-induced hypoglycemia. Glucagon plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon is available under the names Glucagon (Eli Lilly) and GlucaGen or Glucagon Novo Nordisk (Novo Nordisk), which are used to treat severe hypoglycemia in insulin-dependent diabetics.

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 19-kDa prohormone processed into PACAP-related peptide (PRP-48), PACAP-27 and PACAP-38. PACAP stimulates adenylate cyclase in pituitary cells, playing pivotal roles as neurotransmitter and neuromodulator. PACAP belongs to the glucagon family.