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Protein Kinases

BTK Antibody

$265.00
SKU: 254516

BTK (Tyrosine-protein kinase BTK) is a tyrosine kinase that plays a crucial role in B-cell ontogeny. Defects in BTK are the cause of X-linked agammaglobulinemia (XLA) also known as X-linked agammaglobulinemia type 1 (AGMX1) or immunodeficiency type 1 (IMD1). XLA is a humoral immunodeficiency disease which results in developmental defects in the maturation pathway of B-cells. Affected boys have normal levels of pre-B-cells in their bone marrow but virtually no circulating mature B-lymphocytes.

List price: $0.00
Price: $265.00

JNK1 Antibody

$280.00
SKU: 252187
c-Jun N-terminal kinase 1 (JNK1) responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2. This regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. JNK1 phosphorylates heat shock factor protein 4 (HSF4).
List price: $0.00
Price: $280.00

TrkC Antibody

$231.00
SKU: 250897
The Trk family of nerve growth factor receptors includes Trk A, Trk B and Trk C. The prototype member of this gene family, Trk A encodes a 140-kDa cell surface receptor (gp140) expressed in neurons of the sensory spinal and cranial ganglia of neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk A in neural cell lines and embryonic dorsal root ganglia. By comparison, BDNF and to a lesser extent, neurotrophin-3 (NT-3), but not NGF, can induce tyrosine phosphorylation of Trk B gp 145.
List price: $0.00
Price: $231.00

HCLS1 Antibody

$245.00
SKU: 252104
Hematopoietic lineage cell-specific protein (HCLS1) is a substrate of the antigen receptor-coupled tyrosine kinase. HCLS1 plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. HCLS1 is involved in the regulation of gene expression. HCLS1 associates with the SH2 and SH3 domains of LCK. Binding to the LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation.
HCLS1 staining in human fetal tonsil. Paraffin-embedded human fetal tonsil is stained with HCLS1 Antibody (Cat. No. 252104) used at 1:100 dilution.
The HCLS1 Antibody is used in Western blot to detect HCLS1 in Raji cell lysates.
List price: $0.00
Price: $245.00

AEBP1 Peptide

$50.00
SKU: 350560
Adipocyte enhancer-binding protein 1 (AEBP1) up-regulates MAP-kinase activity leading to enhanced proliferation and reduced differentiation of the adipocyte. AEBP1 also up-regulates NF-kappa-B activity in macrophages via phosphorylation and subsequent degradation of I-kappa-B-alpha. This leads to enhanced macrophage inflammatory responsiveness. It can also act as a transcriptional repressor.
List price: $0.00
Storage 
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Price: $50.00
Protein Family 
Translation Factors
Transcription Factors
Protein Kinases
Enzymes
Pathway and Disease 
Immune System
Signaling Molecules and Interaction
Transcription
and Translation.
Format 
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
Alternate Names 
AEBP1; ACLP; AE-binding protein 1; Aortic carboxypeptidase-like protein; Adipocyte enhancer-binding protein 1
Composition 
C93H136N18O36S1C93H136N18O36S1
Sequence 
The synthetic peptide used to raise the antibody Cat. No. 200198 is selected from a sequence within the N-term region of AEBP1. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity 
Purity > 80% by HPLC
Solubility 
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Release Date 
Monday, December 17, 2012
Subcategory 
Synthetic Peptide
Blocking Peptide
MW 
2114.2 g/mol
Unit 
0.1 mg
Accession No.  
Q14113

PIP5K3 Peptide

$50.00
SKU: 350536
The 1-phosphatidylinositol-4-phosphate 5-kinase (PIP5K3) supports the intracellular PIP and PI 4,5-P(2) pools by generating PIP from PI and PI 4,5-P(2) from PI 4-P. PIP5K3 is involved in endosome-related membrane trafficking. Defects in PIP5K3 are the cause of corneal fleck dystrophy.
List price: $0.00
Storage 
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Price: $50.00
Protein Family 
Enzymes
Protein Kinases
Pathway and Disease 
Carbohydrate Metabolism
Cell Motility
Signal Transduction
Format 
Each vial contains 0.1 ml peptide in deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
Alternate Names 
FYVE finger-containing phosphoinositide kinase; 1-phosphatidylinositol-4-phosphate 5-kinase; Phosphatidylinositol-3-phosphate 5-kinase type III; PIP5K; PtdIns(4)P-5-kinase; PIKfyve; p235; PIP5K3
Composition 
C77H127N23O33S1
Sequence 
The synthetic peptide used to raise the antibody Cat. No. 200174 is selected from a sequence within the N-term region of human PIP5K3. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity 
Purity > 80% by HPLC
Solubility 
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Release Date 
Monday, December 17, 2012
Subcategory 
Synthetic Peptide
Blocking Peptide
MW 
1935 g/mol
Unit 
0.1 mg
Accession No.  
Q9Y2I7

AKT Peptide

$50.00
SKU: 350534
RAC-alpha serine/threonine-protein kinase (AKT1) signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as PDGF, EGF, and IGF-I. This antibody may cross-react with AKT1, 2 and 3.
List price: $0.00
Storage 
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Price: $50.00
Protein Family 
Enzymes
Protein Kinases
Pathway and Disease 
Cancers
Cell Communication
Cell Growth and Death
Endocrine System
Immune System
Signal Transduction
Format 
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
Alternate Names 
RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha; Protein kinase B; PKB; C-AKT; AKT1; RAC
Composition 
C92H133N27O29S1
Sequence 
The synthetic peptide used to raise the antibody Cat. No. 200172 is selected from a sequence within the C-term region of human AKT. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity 
Purity > 80% by HPLC
Solubility 
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Release Date 
Monday, December 17, 2012
Subcategory 
Synthetic Peptide
Blocking Peptide
MW 
2113.2 g/mol
Unit 
0.1 mg
Accession No.  
P31749

RET Peptide

$50.00
SKU: 350533
Proto-oncogene tyrosine-protein kinase receptor ret (C-ret) is a tyrosine kinase receptor for DOK2, 4 and 5 important in development. Defects in C-ret are a cause of pheochromocytoma, thyroid carcinoma, neoplasia and neural crest development disorders.
List price: $0.00
Storage 
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Price: $50.00
Protein Family 
Enzymes
Protein Kinases
Receptors and Channels
Pathway and Disease 
Cancers
Development and Behavior
Signaling Molecules and Interaction
Format 
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
Alternate Names 
Proto-oncogene tyrosine-protein kinase receptor ret; C-ret; RET
Composition 
C81H122N26O30S1
Sequence 
The synthetic peptide used to raise the antibody Cat. No. 200171 is selected from a sequence within the C-term region of human RET. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity 
Purity > 80% by HPLC
Solubility 
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Release Date 
Monday, December 17, 2012
Subcategory 
Synthetic Peptide
Blocking Peptide
MW 
1972 g/mol
Unit 
0.1 mg
Accession No.  
P07949

PDGFRA Peptide

$50.00
SKU: 350532
Alpha-type platelet-derived growth factor receptor (PDGFRA), a tyrosine protein kinase, is a receptor that binds both PDGFA and PDGFB. A fusion of PDGFRA and FIP1L1 due to an interstitial chromosomal deletion is the cause of some cases of hypereosinophilic syndrome.
List price: $0.00
Storage 
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Price: $50.00
Protein Family 
Enzymes
Protein Kinases
Receptors and Channels
Pathway and Disease 
Cancers
Cell Communication
Cell Motility
Signaling Molecules and Interaction
Signal Transduction
Format 
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
Alternate Names 
Alpha-type platelet-derived growth factor receptor; PDGF-R-alpha; CD140a antigen; PDGFRA
Composition 
C87H140N28O32S1
Sequence 
The synthetic peptide used to raise the antibody Cat. No. 200170 is selected from a sequence within the C-term region of human PDGFRA. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity 
Purity > 80% by HPLC
Solubility 
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Release Date 
Monday, December 17, 2012
Subcategory 
Synthetic Peptide
Blocking Peptide
MW 
2122.3 g/mol
Unit 
0.1 mg
Accession No.  
P16234

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