Receptors and Channels

Pathway and Disease

Cancers

Cell Communication

Development and Behavior

Signal Transduction

Format

Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.

Alternate Names

Receptor tyrosine-protein kinase erbB-2; EC2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine Kinase-type cell surface receptor HER2; MLN 19; CD340 antigen; ERBB2; HER2; NEU; NGL

Composition

C42H77N9O11

Sequence

Human: H-Ile-Ile-Ser-Ala-Val-Val-Gly-Ile-Leu-OH or H-IISAVVGIL-OH

Purity

Purity > 95% by HPLC

Solubility

Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Release Date

Monday, December 17, 2012

Subcategory

MW

884.12 g/mol

Unit

1 mg

Accession No.

P04626

Glucagon, secreted in the A cells of the islets of Langherans, plays a key role in glucose metabolism and homeostasis. Proglucagon is processed in glucagon, GLP-1, GLP-2, glicentin and oxyntomodulin depending on tissue. Glucagon is used to treat severe hypoglycemia in insulin-dependent diabetics under the names Glucagon (Eli Lilly) and GlucaGen or Glucagon Novo Nordisk (Novo Nordisk).

List price: $0.00

Storage

Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.

Price: $82.92

Protein Family

Pathway and Disease

Signaling molecules and interaction

Format

Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.

Alternate Names

Glucagon; GCG

Composition

C61H89N15O18S1

Sequence

Human: H-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH or H-AQDFVQWLMNT-OH

Purity

Purity > 95% by HPLC

Solubility

Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Release Date

Monday, December 17, 2012

Subcategory

MW

1352.54 g/mol

Unit

2 mg

Accession No.

P01275

Beta-arrestin 1/2 Peptide

$80.00

SKU: 300120

Beta-arrestins function in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein. Beta-arrestin binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adaptor protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). This antibody recognizes beta-arrestin-1 and beta-arrestin-2. The extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type.

List price: $0.00

Storage

Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.

Price: $80.00

Protein Family

Transporters

Pathway and Disease

Signal Transduction

Immune System

Format

Each vial contains 0.1 ml peptide in deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.

Alternate Names

beta-arrestin 1; beta-arrestin 2; beta-arrestin 1/2; Beta-arrestin-1/2; Beta-arrestin-1; Arrestin beta-1; ARRB1; Beta-arrestin-2; Arrestin beta-2; ARRB2

Sequence

The synthetic peptide used to raise the antibody Cat. No. 251344 is selected from a sequence within the N-term region of human beta-arrestin 1/2. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.

Purity

Purity > 80% by HPLC

Solubility

Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Release Date

Monday, December 17, 2012

Subcategory

Unit

0.1 mg

Accession No.

P49407

P32121

Beta-1 Adrenergic Receptor Peptide

$80.00

SKU: 300119

The beta-1 adrenergic receptor (ADRB1) mediates the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The receptor binds epinephrine and norepinephrine with similar affinities. Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.

List price: $0.00

Storage

Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.

Price: $80.00

Protein Family

Pathway and Disease

Nervous and Sensory Systems

Signal Transduction

Format

Each vial contains 0.1 ml peptide in deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.

Alternate Names

Beta-1 adrenergic receptor; Beta-1 adrenoreceptor; Beta-1 adrenoceptor; ADRB1; ADRB1R; B1AR

Composition

C138H201N45O42S3

Sequence

The synthetic peptide used to raise the antibody Cat. No. 250919 is selected from a sequence within the center region of human ADRB1. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.

Purity

Purity > 80% by HPLC

Solubility

Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Release Date

Monday, December 17, 2012

Subcategory

MW

3256.4 g/mol

Unit

0.1 mg

Accession No.

P08588

PAR-4 Peptide

$80.00

SKU: 300118

Proteinase-activated receptor 4 (PAR-4) is a receptor for activated thrombin or trypsin. PAR-4 is coupled to G proteins that stimulate phosphoinositide hydrolysis. PAR-4 plays a role in platelet activation. PAR-4 is widely expressed in tissues, but is not expressed in brain, kidney, spinal cord and peripheral blood leukocytes.

List price: $0.00

Storage

Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.

Price: $80.00

Protein Family

Pathway and Disease

Signaling Molecules and Interaction

Format

Each vial contains 0.1 ml peptide in deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.

Alternate Names

PAR4; Proteinase-activated receptor 4; PAR-4; Thrombin receptor-like 3; Coagulation factor II receptor-like 3; F2RL3

Composition

C84H130N18O26S1

Sequence

The synthetic peptide used to raise the antibody Cat. No. 251564 is selected from a sequence within the C-term region of human PAR-4. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.

Purity

Purity > 80% by HPLC

Solubility

Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Release Date

Monday, December 17, 2012

Subcategory

MW

1838.9 g/mol

Unit

0.1 mg

Accession No.

Q96RI0

IL1RAPL1 Peptide

$80.00

SKU: 300113

X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1) belongs to the interleukin-1 receptor family. IL1RAPL-1 is detected at low levels in heart, skeletal muscle, ovary, skin, amygdala, and brain (caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus). Defects in IL1RAPL1 are the cause of mental retardation X-linked type 21 (MRX21).

List price: $0.00

Storage

Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.

Price: $80.00

Protein Family

Pathway and Disease

Development and Behavior

Immune System

Signaling Molecules and Interaction

Format

Each vial contains 0.1 ml peptide in deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.

Alternate Names

X-linked interleukin-1 receptor accessory protein-like 1; IL1RAPL-1; Oligophrenin-4; Three immunoglobulin domain-containing IL-1 receptor-related 2; TIGIRR-2; IL1RAPL1; OPHN4

Sequence

The synthetic peptide used to raise the antibody Cat. No. 250714 is selected from a sequence within the N-term region of human IL1RAPL1. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.

Purity

Purity > 80% by HPLC

Solubility

Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Release Date

Monday, December 17, 2012

Subcategory

Unit

0.1 mg

Accession No.

Q9NZN1

TLR4 Peptide

$80.00

SKU: 300110

Toll-like receptor family (TLR) has a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. TLRs recognize pathogen-associated molecular patterns (PAMP) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Toll-like receptor 4 (TLR4) cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). TLR4 acts via MYD88, TIRAP and TRAF6 to lead to NFkB activation, cytokine secretion and inflammatory response. TLR4 is highly expressed in placenta, spleen and peripheral blood leukocytes. Genetic variation in TLR4 is associated with age-related macular degeneration 10 (ARMD10), an irreversible vision loss.

List price: $0.00

Storage

Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.

Price: $80.00

Protein Family

Cellular Antigens

Pathway and Disease

Immune System

Infectious Diseases

Signaling Molecules and Interaction

Format

Each vial contains 0.1 ml peptide in deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.

Alternate Names

Toll-like receptor 4; hToll; CD284; TLR4

Sequence

The synthetic peptide used to raise the antibody Cat. No. 251111 is selected from a sequence within the N-term region of human TLR4. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.

Purity

Purity > 80% by HPLC

Solubility

Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Release Date

Monday, December 17, 2012

Subcategory

Unit

0.1 mg

Accession No.

O00206

EMP-1 Peptide

$80.00

SKU: 300108

Tumor-associated membrane protein (EMP-1) is a glycoprotein that is highly expressed in brain tumor cells but not in normal brain. It is also expressed at high levels in undifferentiated embryonic stem cells, but markedly down-regulated in these cells after their differentiation into embryoid bodies. The EMP amino acid sequence bears high homology to the growth arrest specific protein PMP22/GAS-3, which is involved in several human peripheral neuropathies.

List price: $0.00

Storage

Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.

Price: $80.00

Protein Family

Pathway and Disease

Neurodegenerative Disorders

Nervous and Sensory Systems; Signaling Molecules and Interaction

Format

Each vial contains 0.1 ml peptide in deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.

Alternate Names

EMP1; EMP-1; Epithelial membrane protein 1; Tumor-associated membrane protein; CL-20; Protein B4B; TMP

Composition

C60H81N17O19

Sequence

The synthetic peptide used to raise the antibody Cat. No. 251207 is selected from a sequence within the N-term region of human EMP-1. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.

Purity

Purity > 80% by HPLC

Solubility

Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Release Date

Monday, December 17, 2012

Subcategory

MW

1344.4g/mol

Unit

0.1 mg

Accession No.

P54849

NaPi-2b Peptide

$80.00

SKU: 300103

Sodium-dependent phosphate transport protein 2B (NaPi-2b) is involved in actively transporting phosphate into cells via Na+ co-transport. NaPi-2b is the main phosphate transport protein in the intestinal brush border membrane, and has a role in the synthesis of surfactant in lungs' alveoli. Defects in NaPi-2b are a cause of pulmonary alveolar microlithiasis, a rare disease characterized by the deposition of calcium phosphate microliths throughout the lungs.

List price: $0.00

Storage

Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.

Price: $80.00

Protein Family

Pathway and Disease

Membrane Transport

Format

Each vial contains 0.1 ml peptide in deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.

Alternate Names

SLC34A2; NaPi-2b; Sodium-dependent phosphate transport 2B; Sodium-phosphate transport protein 2B; Na(+)-dependent phosphate cotransporter 2B; Sodium/phosphate cotransporter 2B; Na(+)/Pi cotransporter 2B; NaPi3b; Solute carrier family 34 member 2

Composition

C57H100N16O22

Sequence

The synthetic peptide used to raise the antibody Cat. No. 251343 is selected from a sequence within the N-term region of mouse NaPi-2b. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.

Purity

Purity > 80% by HPLC

Solubility

Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Release Date

Monday, December 17, 2012

Subcategory

MW

1360.7 g/mol

Unit

0.1 mg

Accession No.

Q9DBP0

Secretin Receptor Peptide

$80.00

SKU: 300101

The secretin receptor (SCTR) is a multi-pass membrane protein acting as a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cylase. SCTR belongs to the G-protein coupled receptor 2 family.

List price: $0.00

Storage

Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.

Price: $80.00

Protein Family

Pathway and Disease

Signaling Molecules and Interaction

Format

Each vial contains 0.1 ml peptide in deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.

Alternate Names

Secretin receptor; SCT-R; SCTR

Composition

C55H92N16O16

Sequence

The synthetic peptide used to raise the antibody Cat. No. 250854 is selected from a sequence within the N-term region of human secretin receptor. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.

Purity

Purity > 80% by HPLC

Solubility

Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Release Date

Monday, December 17, 2012

Subcategory