Receptors and Channels

Glucagon-like peptide 1 (7-36)amide (GLP-1 (7-36)amide) is the principal active form of GLP-1, the other being GLP-1 (7-37). GLP-1 is a peptide hormone of the glucagon family, produced by the L cells of the intestinal mucosa from the same prohormone as glucagon. The active forms are potent stimulators of glucose-dependent insulin secretion. The sequence of GLP-1 is fully conserved in all mammalian species examined so far.

Exendin-4 is a 39-amino-acid peptide found in venom from the Gila monster Heloderma suspectum. It is a member of the glucagon-secretin family of peptide hormones and neuropeptides. Exendin-4 is a potent agonist of the GLP-1 receptor and hence a potent stimulator of insulin secretion. This antibody is specific for exendin-4 with no cross-reactivity with GLP-1, GLP-2 (human) or glucagon coated on ELISA wells.

Exendin-4 is a 39-amino-acid peptide found in venom from the Gila monster Heloderma suspectum. It is a member of the glucagon-secretin family of peptide hormones and neuropeptides. Exendin-4 is a potent agonist of the GLP-1 receptor and hence a potent stimulator of insulin secretion. This antibody is specific for exendin-4 with no cross-reactivity with GLP-1, GLP-2 (human) or glucagon coated on ELISA wells.

Tumor necrosis factor receptor 2 (TNF-R2) is a high-affinity receptor for TNF-alpha and a low-affinity receptor for lymphotoxin-alpha. TNF-R2 has two isoforms produced by alternative splicing: a cell membrane and a secreted form. The latter blocks TNF-alpha-induced apoptosis, which suggests that this isoform regulates TNF-alpha function by antagonizing its biological activity. A soluble fragment of TNF-R2 (Enbrel, Immunex and Wyeth-Ayerst) is used as treatment of moderate and severe rheumatoid arthritis. This antibody recognizes human TNF-R2 in ELISA and flow cytometry.