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Receptors and Channels

EMP-1 Antibody

$245.00
SKU: 251207
Tumor-associated membrane protein (EMP-1) is a glycoprotein that is highly expressed in brain tumor cells but not in normal brain. It is also expressed at high levels in undifferentiated embryonic stem cells, but markedly down-regulated in these cells after their differentiation into embryoid bodies. The EMP amino acid sequence bears high homology to the growth arrest specific protein PMP22/GAS-3, which is involved in several human peripheral neuropathies.
List price: $0.00
Price: $245.00

TrkC Antibody

$231.00
SKU: 250897
The Trk family of nerve growth factor receptors includes Trk A, Trk B and Trk C. The prototype member of this gene family, Trk A encodes a 140-kDa cell surface receptor (gp140) expressed in neurons of the sensory spinal and cranial ganglia of neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk A in neural cell lines and embryonic dorsal root ganglia. By comparison, BDNF and to a lesser extent, neurotrophin-3 (NT-3), but not NGF, can induce tyrosine phosphorylation of Trk B gp 145.
List price: $0.00
Price: $231.00

CFTR Peptide

$50.00
SKU: 350548
Cystic fibrosis transmembrane conductance regulator (CFTR), a ABC transporter, is involved in the transport of chloride ions and regulates bicarbonate secretion in epithelial cells by regulating the SLC4A7 transporter. CFTR is localized in aggresome bodies when proteasome's degradative capacity is exceeded and lysosomal degradation is engaged via autophagy. Defects in CFTR are the cause of cystic fibrosis.
List price: $0.00
Storage 
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Price: $50.00
Protein Family 
Receptors and Channels
Transporters
Pathway and Disease 
Membrane Transport
Metabolic Disorders
Format 
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
Alternate Names 
Cystic fibrosis transmembrane conductance regulator; CFTR; cAMP-dependent chloride channel; ATP-binding cassette transporter sub-family C member 7; ABCC7
Composition 
C98H160N30O28S1
Sequence 
The synthetic peptide used to raise the antibody Cat. No. 200186 is selected from a sequence within the N-term region of human CFTR. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity 
Purity > 80% by HPLC
Solubility 
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Release Date 
Monday, December 17, 2012
Subcategory 
Synthetic Peptide
Blocking Peptide
MW 
2238.5 g/mol
Unit 
0.1 mg
Accession No.  
P13569

RET Peptide

$50.00
SKU: 350533
Proto-oncogene tyrosine-protein kinase receptor ret (C-ret) is a tyrosine kinase receptor for DOK2, 4 and 5 important in development. Defects in C-ret are a cause of pheochromocytoma, thyroid carcinoma, neoplasia and neural crest development disorders.
List price: $0.00
Storage 
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Price: $50.00
Protein Family 
Enzymes
Protein Kinases
Receptors and Channels
Pathway and Disease 
Cancers
Development and Behavior
Signaling Molecules and Interaction
Format 
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
Alternate Names 
Proto-oncogene tyrosine-protein kinase receptor ret; C-ret; RET
Composition 
C81H122N26O30S1
Sequence 
The synthetic peptide used to raise the antibody Cat. No. 200171 is selected from a sequence within the C-term region of human RET. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity 
Purity > 80% by HPLC
Solubility 
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Release Date 
Monday, December 17, 2012
Subcategory 
Synthetic Peptide
Blocking Peptide
MW 
1972 g/mol
Unit 
0.1 mg
Accession No.  
P07949

PDGFRA Peptide

$50.00
SKU: 350532
Alpha-type platelet-derived growth factor receptor (PDGFRA), a tyrosine protein kinase, is a receptor that binds both PDGFA and PDGFB. A fusion of PDGFRA and FIP1L1 due to an interstitial chromosomal deletion is the cause of some cases of hypereosinophilic syndrome.
List price: $0.00
Storage 
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Price: $50.00
Protein Family 
Enzymes
Protein Kinases
Receptors and Channels
Pathway and Disease 
Cancers
Cell Communication
Cell Motility
Signaling Molecules and Interaction
Signal Transduction
Format 
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
Alternate Names 
Alpha-type platelet-derived growth factor receptor; PDGF-R-alpha; CD140a antigen; PDGFRA
Composition 
C87H140N28O32S1
Sequence 
The synthetic peptide used to raise the antibody Cat. No. 200170 is selected from a sequence within the C-term region of human PDGFRA. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity 
Purity > 80% by HPLC
Solubility 
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Release Date 
Monday, December 17, 2012
Subcategory 
Synthetic Peptide
Blocking Peptide
MW 
2122.3 g/mol
Unit 
0.1 mg
Accession No.  
P16234

NF2 Peptide

$50.00
SKU: 350518
Merlin (NF2) acts as a membrane stabilizing protein and may inhibit PI3 kinase by binding to CENTG1. Defects in NF2 are the cause of neurofibromatosis 2 and schwannnomatosis (neuromas).
List price: $0.00
Storage 
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Price: $50.00
Protein Family 
Receptors and Channels
Pathway and Disease 
Cancers
Nervous and Sensory Systems
Format 
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
Alternate Names 
Merlin; Moesin-ezrin-radixin-like protein; neurofibromin-2; Schwannomin; Schwannomerlin; NF2; SCH
Composition 
C86H155N29O26S1
Sequence 
The synthetic peptide used to raise the antibody Cat. No. 200156 is selected from a sequence within the C-term region of human NF2. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity 
Purity > 80% by HPLC
Solubility 
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Release Date 
Monday, December 17, 2012
Subcategory 
Synthetic Peptide
Blocking Peptide
MW 
2043.4 g/mol
Unit 
0.1 mg
Accession No.  
P35240

BMPR1A Peptide

$50.00
SKU: 350513
Upon ligand binding, BMPR1A forms a receptor complex consisting of two type II and two type I transmembrane Ser/Thr kinases. The type I receptors are activated by the type II receptors by using a phosphorylation mechanism, and subsequently bind SMAD transcriptional regulators. Defects in BMPR1A are the cause of juvenile polyposis syndrome, Cowden disease and hereditary mixed polyposis syndrome 2, which lead to gastrointestinal, breast, thyroid, endometrial and colon cancers.
List price: $0.00
Storage 
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Price: $50.00
Protein Family 
Cellular Antigens
Enzymes
Protein Kinases
Receptors and Channels
Pathway and Disease 
Cancers
Signal Transduction
Signaling Molecules and Interaction
Format 
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
Alternate Names 
Bone morphogenetic protein receptor type IA; Serine/threonine-protein kinase receptor R5; SKR5; Activin receptor-like kinase 3; ALK-3; CD292 antigen; BMPR1A; ACVRLK3
Composition 
C77H126N22O34S1
Sequence 
The synthetic peptide used to raise the antibody Cat. No. 200151 is selected from a sequence within the N-term region of human BMPR1A. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity 
Purity > 80% by HPLC
Solubility 
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Release Date 
Monday, December 17, 2012
Subcategory 
Synthetic Peptide
Blocking Peptide
MW 
1936 g/mol
Unit 
0.1 mg
Accession No.  
P36894

PTCH1 Peptide

$50.00
SKU: 350500
PTCH1 is a receptor for sonic hedgehog, indian hedgehog and desert hedgehog that associates with the smoothened protein to transduce the hedgehog's protein signal. Defects in PTCH1 are the cause of several structural anomalies of the brain such as the basal cell nevus syndrome and holoprosencephaly type 7.
List price: $0.00
Storage 
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Price: $50.00
Protein Family 
Receptors and Channels
Pathway and Disease 
Cancers
Development and Behavior
Signal Transduction
Format 
Each vial contains 0.1 ml peptide in deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
Alternate Names 
Protein patched homolog 1; PTC; PTC1; PTCH1; PTCH
Composition 
C84H143N25O32S1
Sequence 
The synthetic peptide used to raise the antibody Cat. No. 200138 is selected from a sequence within the C-term region of human PTCH1. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity 
Purity > 80% by HPLC
Solubility 
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Release Date 
Monday, December 17, 2012
Subcategory 
Synthetic Peptide
Blocking Peptide
MW 
2047.2 g/mol
Unit 
0.1 mg
Accession No.  
Q13635

TYRO10 Peptide

$50.00
SKU: 350493
TYRO10 (DDR2) is a tyrosine kinase receptor for fibrillar collagen that mediates fibroblast migration and proliferation. TYRO10 contributes to cutaneous wound healing.
List price: $0.00
Storage 
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Price: $50.00
Protein Family 
Enzymes
Protein Kinases
Receptors and Channels
Pathway and Disease 
Cell Motility
Signaling Molecules and Interaction
Format 
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
Alternate Names 
Discoidin domain-containing receptor 2; Discoidin domain receptor 2; DDR2; Receptor protein-tyrosine kinase TKT; Tyrosine-protein kinase TYRO 10; Neurotrophic tyrosine kinase, receptor-related 3; CD167b antigen; NTRKR3
Composition 
C92H126N22O29S1
Sequence 
The synthetic peptide used to raise the antibody Cat. No. 200131 is selected from a sequence within the center region of human TYRO10. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity 
Purity > 80% by HPLC
Solubility 
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Release Date 
Monday, December 17, 2012
Subcategory 
Synthetic Peptide
Blocking Peptide
MW 
2036.2 g/mol
Unit 
0.1 mg
Accession No.  
Q16832

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