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SNAREs

Hamartin Peptide

$50.00
SKU: 350508
Hamartin (TSC1) is involved in vesicular transport and docking with TSC2. Hamartin is a tumor suppressor. Defects in hamartin are the cause of tuberous sclerosis complex (TSC), a multi-system disorder.
List price: $0.00
Storage 
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Price: $50.00
Protein Family 
SNAREs
Pathway and Disease 
Cancers
Development and Behavior
Endocrine System
Signal Transduction
Format 
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
Alternate Names 
Tuberous sclerosis 1 protein; TSC1; TSC; Hamartin
Composition 
C82H118N26O27S2
Sequence 
The synthetic peptide used to raise the antibody Cat. No. 200146 is selected from a sequence within the C-term region of human hamartin. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity 
Purity > 80% by HPLC
Solubility 
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Release Date 
Monday, December 17, 2012
Subcategory 
Synthetic Peptide
Blocking Peptide
MW 
1964.1 g/mol
Unit 
0.1 mg
Accession No.  
Q92574

Synapsin I Antibody

$330.00
SKU: 253218

Synapsin I plays a key role in synaptic plasticity in brain. This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. In addition to its role in plasticity, the expression of synapsin I is a precise indicator of synapse formation. Thus, synapsin I immunocytochemistry provides a valuable tool for the study of synaptogenesis. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation.

The Synapsin I Antibody (Cat. No. 253218) is used in Western blot to detect Synapsin I in rat hippocampal tissue lysates.
List price: $0.00
Price: $330.00

Syntaxin Antibody

$330.00
SKU: 253224
Syntaxins are a family of proteins involved in the docking of synaptic vesicles with the plasma membrane. Syntaxin, along with synaptobrevin and SNAP-25, forms the SNARE complex which mediates synaptic vesicle fusion and exocytosis. Binding of Munc18-1 to the N-terminus of syntaxin 1 has been demonstrated to be essential for exocytic membrane fusion. Decreased levels of phosphorylated syntaxin 1 in the prefrontal cortex have been correlated with schizophrenia.
List price: $0.00
Price: $330.00

Synaptotagmin 1 Antibody

$330.00
SKU: 253223
SYT1 (Synaptotagmin) is widely regarded as the primary calcium sensor for synaptic vesicle exocytosis. Synaptotagmin can be phosphorylated by multiple protein kinases and this plays a key role in modulation of synaptotagmin’s ability to influence both the exocytotic and endocytotic components of synaptic transmission.
List price: $0.00
Price: $330.00

Synaptojanin 1 Antibody

$330.00
SKU: 253221
Synaptojanin is a phosphatidylinositol phosphatase involved in clathrin-mediated endocytosis of synaptic vesicles. Synaptojanin 1 has two alternatively spliced isoforms; one that is ~ 145 kDA and is exclusively expressed in neurons, and a 70 kDa isoform which is expressed in non neuronal, peripheral tissues. Defects in synaptojanin have been linked to Donwn’s syndrome.
List price: $0.00
Price: $330.00

Synaptobrevin Antibody

$330.00
SKU: 253220
Synaptobrevin (VAMP) is an integral membrane protein of synaptic vesicles that plays a major role in the formation of larger SNARE complexes, along with SNAP-25 and syntaxin. Synaptobrevin has been shown to be essential for two fast synapse-specific membrane trafficking processes: fast exocytosis for neurotransmitter release and fast endocytosis that mediates rapid recycling of synaptic vesicles Decreased levels of synaptobrevin in human hippocampus and cortex have been correlated with cognitive defects in Alzheimer’s disease.
List price: $0.00
Price: $330.00

Synapsin I Antibody

$280.00
SKU: 253219
Synapsin I plays a key role in synaptic plasticity in brain. This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. In addition to its role in plasticity, the expression of synapsin I is a precise indicator of synapse formation. Thus, synapsin I immunocytochemistry provides a valuable tool for the study of synaptogenesis. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation.
List price: $0.00
Price: $280.00

SNAP25 Antibody

$330.00
SKU: 253216
SNAP25 (Synaptosomal associated protein of 25 kDa) is a presynaptic plasma membrane protein that is widely distributed throughout the brain and involved in the regulation of neurotransmitter release. Decreased levels of SNAP25 have been found in the brains of patients with Down Syndrome and Alzheimer’s Disease. In addition, a significant reduction in the hippocampal expression of SNAP25 has also been found in patients with Schizophrenia.
List price: $0.00
Price: $330.00

Rabphilin 3A Antibody

$330.00
SKU: 253208
Rabphilin-3A is a peripheral membrane protein that binds Ca2+ and phospholipids and is attached to synaptic vesicle membranes. The expression of rabphilin 3A is reduced in an animal model of Huntington’s disease. Rabphilin can be phosphorylated at Ser234 by both CAM kinase II and PKA and this phosphorylation has been suggested to regulate neuronal activity during development in a synapse-specific manner.
List price: $0.00
Price: $330.00

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