Human Fractalkine

The soluble form of fractalkine is a chemotactic factor for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of leukocytes to endothelial cells. Fractalkine plays a role in regulating leukocyte adhesion and migration processes at the endothelium, and it binds to CX3CR1. Recombinant fractalkine comprises a 76 amino acid fragment (25-100) corresponding to the chemokine domain of the human fractalkine protein and is expressed in E. coli with an amino-terminal hexahistidine tag.