Human Resistin

Resistin is a member of a class of cysteine rich proteins and is also known as ‘serine/cysteine rich adipocytesepcific secretory factor’ or ADSF or FIZZ3. Resistin is secreted by adipose tissue and has been implicated in the pathogenesis of obesity-mediated insulin resistance and type II diabetes. Resistin also appears to act as a proinflammatory cytokine. Recombinant resistin comprises a 92 amino acid fragment (17-108) corresponding to the mature resistin protein and is expressed in E. coli with an amino-terminal hexahistidine tag.