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Mouse IP-10

Recombinant Active Protein
Cat. No. 
600199
Unit 
0.025 mg
Price $235.00

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Abbiotec

7985 Dunbrook Rd., Ste A
San Diego, CA 92126, USA

Phone: 1 858 586 0500,
1 800 854 7453
Fax: 1 858 586 6252
Email: info@abbiotec.com
Description 
Among CXC chemokines, CXCL10 has been identified to play an important role in several endocrine eautoimmune diseases such as Hashimoto's thyroiditis, Grave's disease and Type 1 diabetes mellitus. The chemokine IP-10 (interferon-inducible protein of 10 kDa, CXCL10) is a chemoattractant for CXCR3+ T cells, binds to the G protein-coupled receptor CXCR3, which is found mainly on activated T cells and NK cells, and plays an important role in Th1-type inflammatory diseases. IP-10 also binds to glycosaminoglycans (GAGs), an interaction thought to be important for its sequestration on endothelial and other cells. Recombinant Mouse IP-10 produced in E. coli is a single non-glycosylated polypeptide chain containing 77 amino acids with a MW of 8,701 Da.