Ph. 858 586 0500    Toll Free 800 854 7453

Activated Protein C Antibody

Mouse Monoclonal Antibody
Cat. No. 
250212
Unit 
0.2 mg
Price $692.00

Order

Order directly from

Abbiotec

350 W. 9th Ave., Ste 107
Escondido, CA 92025, USA

Phone: 1 858 586 0500 x100,
1 800 854 7453
Fax: 1 858 586 6252
Email: info@abbiotec.com
Description 

Protein C is a vitamin K-dependent serine protease produced in the liver and made up of 2 polypeptide chains. The 62kDa proenzyme is activated by thrombin and the active enzyme cleaves factor Va and VIIIa and thus inhibits blood coagulation. The molecular weight of the active enzyme is 55kDa and the normal concentrations in human plasma is approximately 1-3 ng/ml because of the very fast turnover, the proenzyme concentration is approximately 3 µg/ml. The activated protein C (APC) is inhibited by members of the serine protease inhibitor (serpin) family, of which alpha1-antitrypsin (AAT) and protein C inhibitor (PCI) are the most important. This antibody is specific for a conformation-dependent neoepitope that is expressed in activated protein C upon complex-formation with alpha1-antitrypsin. No reaction is seen to non-complexed alpha1-antitrypsin and weak cross-reaction with protein C zymogen. The antibody specificity is calcium dependent.