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ADAM 15 Antibody

Rabbit Polyclonal Antibody
Cat. No. 
251996
Unit 
0.1 mg
Price $307.00

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Abbiotec

350 W. 9th Ave., Ste 107
Escondido, CA 92025, USA

Phone: 1 858 586 0500 x100,
1 800 854 7453
Fax: 1 858 586 6252
Email: info@abbiotec.com
Description 

Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) is a metalloproteinase with gelatinolytic and collagenolytic activity. ADAM 15 plays a role in the wound healing process, mediating both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. ADAM 15 inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. ADAM 15 suppresses cell motility towards fibronectin by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. ADAM 15 cleaves E-cadherin in response to growth factor deprivation.