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B7-H4 Antibody

Rabbit Polyclonal Antibody
Cat. No. 
250473
Unit 
0.1 mg
Price $347.00

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Abbiotec

350 W. 9th Ave., Ste 107
Escondido, CA 92025, USA

Phone: 1 858 586 0500 x100,
1 800 854 7453
Fax: 1 858 586 6252
Email: info@abbiotec.com
Description 

Immune costimulatory protein B7-H4 (B7-H4) is expressed on the surface of a variety of immune cells and functions as a negative regulator of T cell response. By arresting cell cycle, B7-H4 inhibits growth, cytokine secretion and cytotoxicity development. When expressed on the cell surface of tumor macrophages, B7-H4 plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. B7-H4 is also involved in promoting epithelial cell transformation. B7-H4 can be a predictive marker for renal cell carcinoma.