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B7-H4 Antibody

Rabbit Polyclonal Antibody

Cat. No.

250473

Unit

0.1 mg

Price $347.00

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Order directly from

Abbiotec

350 W. 9th Ave., Ste 107
Escondido, CA 92025, USA

Phone: 1 858 586 0500 x100,
1 800 854 7453

Fax: 1 858 586 6252

Email: info@abbiotec.com

Website: http://www.abbiotec.com

Description

Immune costimulatory protein B7-H4 (B7-H4) is expressed on the surface of a variety of immune cells and functions as a negative regulator of T cell response. By arresting cell cycle, B7-H4 inhibits growth, cytokine secretion and cytotoxicity development. When expressed on the cell surface of tumor macrophages, B7-H4 plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. B7-H4 is also involved in promoting epithelial cell transformation. B7-H4 can be a predictive marker for renal cell carcinoma.

Spec Container

Datasheet

Data Left

Isotype

Rabbit Ig

Applications

IHC

Species Reactivity

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Alternate Names

V-set domain-containing T-cell activation inhibitor 1; Immune costimulatory protein B7-H4; B7h.5; T-cell costimulatory molecule B7x; Protein B7S1; VTCN1; B7H4

Data Right

Accession No.

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Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the center region of human B7-H4.

Application Notes

E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-500

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Images

B7-H4 staining in human lung cancer. Paraffin-embedded human lung cancer tissue is stained with B7-H4 Antibody (Cat. No. 250473) used at 1:200 dilution.

Citations

Product Citations

[1] Zhao X et al. 2016. Oncol Rep. 36(1): 419-27. PMID 27177355. [2] Galazka K et al. 2012. American Journal of Reproductive Immunology. 68(1):85-93. PMID 22530960. [3]Basta P et al. American Journal of Reproductive Immunology. 65(2):164-172. PMID 20645939. [4] Arigami T et al. 2011. Medicine. World Journal of Surgery. 35(9):2051-2057. PMID 21748517. [5] Jung S et al. Korean Journal of Urology. 2011. 52(2): 90-95. PMID 21379424.