CULLIN Antibody
Rabbit Polyclonal Antibody
Cat. No.
250489
Unit
0.1 mg
Price
$323.00
Order
Order directly from
Abbiotec
350 W. 9th Ave., Ste 107
Escondido, CA 92025, USA
Phone: 1 858 586 0500 x100,
1 800 854 7453
1 800 854 7453
Fax: 1 858 586 6252
Email: info@abbiotec.com
Website: http://www.abbiotec.com
Description
Cullin (Cullin-1, CUL1) is a core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, cullin serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. Cullin contributes to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.