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IASPP Antibody

Rabbit Polyclonal Antibody
Cat. No. 
250704
Unit 
0.1 mg
Price $323.00

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Abbiotec

350 W. 9th Ave., Ste 107
Escondido, CA 92025, USA

Phone: 1 858 586 0500 x100,
1 800 854 7453
Fax: 1 858 586 6252
Email: info@abbiotec.com
Description 
IASPP (Inhibitory member of the ASPP family, RelA-associated inhibitor, Inhibitor of ASPP protein, Protein iASPP, PPP1R13B-like protein, NFkB-interacting protein 1, PPP1R13L ) is a regulator that plays a central role in the regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. IASPP blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. It also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.