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MAPK1 (activated) Antibody

Mouse Monoclonal Antibody
Cat. No. 
251762
Unit 
0.1 mg
Price $292.00

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Abbiotec

7985 Dunbrook Rd., Ste A
San Diego, CA 92126, USA

Phone: 1 858 586 0500 x100,
1 800 854 7453
Fax: 1 858 586 6252
Email: info@abbiotec.com
Description 
Mitogen-activated protein kinase 1 (MAP kinase 1) is involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. MAP kinase 1 acts as a transcriptional repressor. MAP kinase 1 binds to a [GC]AAA[GC] consensus sequence. MAP kinase 1 represses the expression of interferon gamma-induced genes. MAPK1 is activated by phosphorylation on Thr-185 and Tyr-187 in response to insulin and NGF. Both phosphorylations are required for activity. This antibody binds to the diphosphorylated form.