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Osteoprotegerin Antibody

Rabbit Polyclonal Antibody
Cat. No. 
250800
Unit 
0.1 mg
Price $323.00

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350 W. 9th Ave., Ste 107
Escondido, CA 92025, USA

Phone: 1 858 586 0500 x100,
1 800 854 7453
Fax: 1 858 586 6252
Email: info@abbiotec.com
Description 

Osteoprotegerin (OPG) acts as a decoy receptor for RANKL by neutralizing its function in osteoclastogenesis. OPG inhibits osteoclast activation and promotes osteoclast apoptosis in vitro. OPG is up-regulated by increasing calcium concentration and estrogens. Defects in OPG are the cause of juvenile Paget disease, which is characterized by rapid bone remodeling leading to deformities, fractures ans osteopenia.