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Shank1 Antibody

Rabbit Polyclonal Antibody
Cat. No. 
250856
Unit 
0.1 mg
Price $323.00

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Abbiotec

350 W. 9th Ave., Ste 107
Escondido, CA 92025, USA

Phone: 1 858 586 0500 x100,
1 800 854 7453
Fax: 1 858 586 6252
Email: info@abbiotec.com
Description 
SH3 and multiple ankyrin repeat domains protein 1 (Shank1) is an adaptor protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, as well as in the actin based cytoskeleton. Shank1 plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Shank1 is expressed in the brain, particularly in the amygdala, hippocampus, substantia nigra and thalamus.