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TNF-alpha Antibody

Rabbit Polyclonal Antibody

Cat. No.

251900

Unit

0.1 mg

Price $323.00

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Order directly from

Abbiotec

350 W. 9th Ave., Ste 107
Escondido, CA 92025, USA

Phone: 1 858 586 0500 x100,
1 800 854 7453

Fax: 1 858 586 6252

Email: info@abbiotec.com

Website: http://www.abbiotec.com

Description

Tumor necrosis factor alpha (TNF-alpha) is a cytokine that binds to the TNF-R1 and TNF-R2 receptors. TNF-alpha is mainly secreted by macrophages and induces cell death of certain tumor cell lines. It is a potent pyrogen causing fever by direct action or by stimulation of IL-1 secretion, and therefore found in cachexia accompanying diverse cancers and infections. Genetic variations in TNF are associated with susceptibility to psoriatic arthritis and to HBV infection.

Spec Container

Datasheet

Data Left

Isotype

Rabbit Ig

Applications

IHC

Species Reactivity

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by immunogen-affinity chromatography.

Alternate Names

Tumor necrosis factor; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin; TNF; TNFA; TNFSF2

Data Right

Accession No.

P01375

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human TNF-alpha.

Application Notes

E: 1:1,000-1:5,000; WB: 1:100-1:500; IHC: 1:100-1:500

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Images

TNF-alpha staining in human mammary cancer. Paraffin-embedded human mammary cancer is stained with TNF-alpha (Cat. No. 251900) used at 1:200 dilution.

The TNF-alpha (Cat. No. 251900) is used in Western blot at 1:100 dilution to detect 1 ng human TNF-alpha (lane 1), 100 ng mouse and rat TNF-alpha (lane 2 and 3).

Citations

Product Citations

[1] Mulas G et al. 2016. Exp Neurol. 286: 83-92. PMID 27697481. [2] Pova TF et al. 2016. PLoS One. 11(12):e0168973. PMID 28006034. [3] Hwang J-H. et al. 2013. PLoS ONE. 8(4):e60730. PMID 23637762. [4] Carta A et al. 2011. Neuroscience. 194:250-261. PMID 21839812. [5] Pisanu A et al. 2014. Neurobiol Dis. 71: 280-91. PMID 25134730.