Ph. 858 586 0500    Toll Free 800 854 7453

TNF-R2 Antibody

Mouse Monoclonal Antibody
Cat. No. 
0.1 mg
Price $299.00


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Escondido, CA 92025, USA

Phone: 1 858 586 0500 x100,
1 800 854 7453
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Tumor necrosis factor receptor 2 (TNF-R2) is a high-affinity receptor for TNF-alpha and a low-affinity receptor for lymphotoxin-alpha. TNF-R2 has two isoforms produced by alternative splicing: a cell membrane and a secreted form. The latter blocks TNF-alpha-induced apoptosis, which suggests that this isoform regulates TNF-alpha function by antagonizing its biological activity. A soluble fragment of TNF-R2 (Enbrel, Immunex and Wyeth-Ayerst) is used as treatment of moderate and severe rheumatoid arthritis. This antibody recognizes human TNF-R2 in ELISA and flow cytometry.