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Trim5 alpha (3B11) Antibody

Mouse Monoclonal Antibody
Cat. No. 
252615
Unit 
0.1 ml
Price $388.00

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Abbiotec

350 W. 9th Ave., Ste 107
Escondido, CA 92025, USA

Phone: 1 858 586 0500 x100,
1 800 854 7453
Fax: 1 858 586 6252
Email: info@abbiotec.com
Description 
TRIM5-alpha (Tripartite motif-containing protein 5) is a protein that is found in the cells of many mammals and fends off various retrovirus infections. It protects monkeys from infection with HIV-1 and humans from infection with some other viruses. If a retrovirus has entered a cell, it needs to shed its capsid in order to reversely transcribe its genes, so that they can be expressed by the host cell. It is believed that TRIM5 alpha, which is present in the cytoplasm, somehow recognizes the capsid and blocks its shedding, thereby stopping the virus in its tracks. It thus represents an intracellular defense completely separate from the rest of the body's immune system.