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SYVN1 Peptide

Synthetic Peptide
Blocking Peptide
Cat. No. 
350470
Unit 
0.1 mg
Price $55.00

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Abbiotec

350 W. 9th Ave., Ste 107
Escondido, CA 92025, USA

Phone: 1 858 586 0500 x100,
1 800 854 7453
Fax: 1 858 586 6252
Email: info@abbiotec.com
Description 
Synoviolin (SYVN1) acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates subsequently promoting their degradation. For instance, SYVN1 protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. SYVN1 is up-regulated in synovial tissues from patients with rheumatoid arthritis.