Recombinant Active Protein
Nerve Growth Factor (NGF) is the first of a series of neurotrophic factors that were found to influence the growth and differentiation of sympathetic and sensory neurons. It is comprised of alpha, beta, and gamma subunits. The beta subunit is responsible for its growth-stimulating activity. The synthesis of NGF in astrocytes is enhanced by various other cytokines: IL-1, TNF-alpha, PDGF and TGF-beta. Mouse beta-NGF produced in the submaxillary gland is a homodimer consisting of two identical 120 amino acid non-glycosylated polypeptide chains with a MW of 13,471 Da each.