Recombinant Active Protein
TNF Receptor 1 (TNFR1) is expressed in most tissues and is activated by soluble and membrane-bound TNFalpha. TNFR1 is known to activate NF-kB and MAPK pathways to induce inflammation, promote apoptotic cell death, inhibit tumorigenesis and inhibit viral replication. Recombinant soluble TNFR1 is produced in E.coli. The soluble form of recombinant human TNFR1 is a non-glycosylated protein, containing 162 amino acids, with a molecular weight of 18.3 kDa.