HSP-60 Antibody

Heat shock protein 60 (HSP-60) is involved in mitochondrial protein import and macromolecular assembly. HSP-60 facilitates the correct folding of imported proteins. HSP-60 also prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. Defects in HSPD1 are a cause of spastic paraplegia autosomal dominant type 13 (SPG13). Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.