Human VEGF-165

Vascular Endothelial Growth Factor (VEGF) is a heparin-binding glycoprotein which can exist in a number of different isoforms. The protein has been found to be a potent inducer of angiogeneis and endothelial cell proliferation, and plays an important role in regulating vasculogenesis. VEGF can be detected in both the plasma and serum and has been implicated in several disease states associated with augmented angiogenesis. Recombinant VEGF-165 comprises a 165 amino acid fragment (5-169) corresponding to the VEGF 165 isoform and is expressed in E. coli with an amino-terminal hexahistidine tag.