Recombinant Active Protein
Transforming growth factor-beta (TGF beta) consists of multifunctional peptides that regulate growth and differentiation in a variety of cells. The transforming growth factor beta (TGF-beta) family of growth modulators play critical roles in tissue development and maintenance. Recent data suggest that individual TGF-beta isoforms (TGF-beta 1, -beta 2 and -beta 3) have overlapping yet distinct biological actions and target cell specificities, both in developing and adult tissues Transforming growth factor (TGF) beta 3 is a new isoform of the TGF beta superfamily and is presumed to play an important role in wound repair and scarring. TGF-beta 3 is believed to be involved in osteoblast proliferation, chemotaxis, and collagen synthesis. Defects in TGF-beta 3 are a cause of familial arrhythmogenic right ventricular dysplasia type 1 (ARVD1), also known as arrhythmogenic right ventricular cardiomyopathy. ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. Recombinant Human TGF-b 3 produced in E. coli is a disulfide-linked homodimeric non-glycosylated polypeptide chain containing 112 amino acids with a MW of 25,445 Da.